LUC7L2

Entrez Summary: This gene encodes a protein that contains a C2H2-type zinc finger, coiled-coil region and arginine, serine-rich (RS) domain. A similar protein in mouse interacts with sodium channel modifier 1, and the encoded protein may be involved in the recognition of non-consensus splice donor sites in association with the U1 snRNP spliceosomal subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011].
UniProt Summary: May bind to RNA via its Arg/Ser-rich domain.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Nifuroxazide 5μM R03 exp102	-3.23
Colchicine 0.009μM R05 exp215	-2.79
TNF-alpha 44ng/ml R08 exp533	-2.28
Etoposide 0.1μM R05 exp198	-2.2
MLN-4924 0.2μM R00 exp21	-2.18
Oligomycin-A 2μM R00 exp25	-2.14
Rapamycin 0.001μM R08 exp429	-2.14
UM0131023 0.05μM R05 exp248	-1.94
Vemurafenib 6.6μM R02 exp89	-1.87
Thalidomide 20μM R07 exp406	-1.86
L-74142 5μM R03 exp131	-1.76
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	-1.75
Chlorpromazine 10μM R07 exp344	-1.73
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	-1.72
2-Methoxyestradiol 0.2μM R01 exp40	-1.71
PFI-3 10μM R03 exp144	-1.7
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	-1.7
THZ1 0.06μM R08 exp531	-1.7
2-Deoxy-D-glucose 800μM R05 exp214	1.73
CFI-400945 25μM R08 exp469	1.82
CB-5083 0.4μM R08 exp468	2.02
UM0125461 0.74μM R02 exp84	2.51

Global Fraction of Cell Lines Where Essential: 9/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/28
bone	1/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	1/16
kidney	2/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

U2-type prespliceosome
U1 snRNP
mRNA splice site selection
spliceosomal complex assembly
mRNA binding
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions
enzyme binding
RNA splicing
nuclear speck
ribonucleoprotein complex biogenesis
mRNA processing
mRNA metabolic process
cellular protein-containing complex assembly
RNA processing
RNA binding
protein-containing complex assembly
RNA metabolic process
protein-containing complex subunit organization
gene expression