LY86

Entrez Summary: N/A
UniProt Summary: May cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Important for efficient CD180 cell surface expression (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

positive regulation of lipopolysaccharide-mediated signaling pathway
regulation of lipopolysaccharide-mediated signaling pathway
positive regulation of response to biotic stimulus
inflammatory response
positive regulation of multi-organism process
regulation of response to biotic stimulus
positive regulation of response to external stimulus
innate immune response
regulation of multi-organism process
defense response to other organism
regulation of response to external stimulus
response to other organism
response to external biotic stimulus
response to biotic stimulus
defense response
extracellular space
positive regulation of signal transduction
positive regulation of cell communication
positive regulation of signaling
immune response