LYZL6

Entrez Summary: N/A
UniProt Summary: May be involved sperm-egg plasma membrane adhesion and fusion during fertilization (PubMed:28182716). Exhibits bacteriolytic activity in vitro against Micrococcus luteus and Staphylococcus aureus (PubMed:28182716, PubMed:24013621). Shows weak bacteriolytic activity against Gram-positive bacteria at physiological pH (PubMed:28182716). Bacteriolytic activity is pH- dependent, with a maximum at around pH 5.6 (PubMed:28182716). {ECO:0000269|PubMed:24013621, ECO:0000269|PubMed:28182716}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
VER-155008 3.9μM R06 exp301	1.83
LLY-283 2.6μM R06 exp290	2.02

SLT
Lys

sperm plasma membrane
lysozyme activity
fusion of sperm to egg plasma membrane involved in single fertilization
plasma membrane fusion
sperm midpiece
cytolysis
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
membrane fusion
single fertilization
fertilization
defense response to bacterium
cellular process involved in reproduction in multicellular organism
cell surface
response to bacterium
sexual reproduction
multicellular organism reproduction
membrane organization
defense response to other organism
multi-organism reproductive process
response to other organism
response to external biotic stimulus
response to biotic stimulus
defense response
reproductive process
reproduction
extracellular region