MAFA

Entrez Summary: N/A
UniProt Summary: Acts as a transcriptional factor. Specifically binds the insulin enhancer element RIPE3b and activates insulin gene expression. Cooperates synergistically with NEUROD1 and PDX1. Phosphorylation by GSK3 increases its transcriptional activity and is required for its oncogenic activity. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. {ECO:0000269|PubMed:12011435, ECO:0000269|PubMed:12368292, ECO:0000269|PubMed:15665000, ECO:0000269|PubMed:15993959, ECO:0000269|PubMed:18042454, ECO:0000269|PubMed:19143053}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

bZIP Maf
Maf N

nitric oxide mediated signal transduction
insulin secretion
peptide hormone secretion
hormone secretion
hormone transport
response to glucose
response to hexose
response to monosaccharide
protein secretion
establishment of protein localization to extracellular region
protein localization to extracellular region
signal release
response to carbohydrate
peptide secretion
second-messenger-mediated signaling
sequence-specific DNA binding
DNA-binding transcription activator activity, RNA polymerase II-specific
protein heterodimerization activity
RNA polymerase II proximal promoter sequence-specific DNA binding
regulation of hormone levels
DNA-binding transcription factor activity
protein homodimerization activity
secretion by cell
export from cell
cell-cell signaling
secretion
positive regulation of transcription by RNA polymerase II
DNA binding
protein transport
peptide transport
positive regulation of transcription, DNA-templated
response to oxygen-containing compound
DNA-binding transcription factor activity, RNA polymerase II-specific
amide transport
establishment of protein localization
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
intracellular signal transduction
positive regulation of RNA metabolic process
nitrogen compound transport