MAGEA1
Gene Information
- Official Symbol: MAGEA1
- Official Name: MAGE family member A1
- Aliases and Previous Symbols: N/A
- Entrez ID: 4100
- UniProt: P43355
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. [provided by RefSeq, Jul 2008].
- UniProt Summary: May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. {ECO:0000269|PubMed:15316101}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 12960
- Expression level (log2 read counts): -6.6
MAGEA1 Expression in NALM6 Cells: -6.6
