MAGI3

Official Symbol: MAGI3
Official Name: membrane associated guanylate kinase, WW and PDZ domain containing 3
Aliases and Previous Symbols: N/A
Entrez ID: 260425
UniProt: Q5TCQ9
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: N/A
UniProt Summary: Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2. {ECO:0000269|PubMed:10748157}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
BI-6727 0.0125μM R03 exp97	1.79
MKC9989 10μM R03 exp133	1.88

guanylate kinase activity
GDP metabolic process
GMP metabolic process
purine ribonucleoside monophosphate metabolic process
purine nucleoside monophosphate metabolic process
guanosine-containing compound metabolic process
molecular adaptor activity
ribonucleoside monophosphate metabolic process
purine ribonucleoside metabolic process
purine nucleoside diphosphate metabolic process
purine ribonucleoside diphosphate metabolic process
purine nucleoside metabolic process
ribonucleoside diphosphate metabolic process
nucleoside monophosphate metabolic process
ribonucleoside metabolic process
nucleoside diphosphate metabolic process
nucleoside metabolic process
bicellular tight junction
glycosyl compound metabolic process
cell-cell junction
regulation of JNK cascade
regulation of stress-activated MAPK cascade
regulation of stress-activated protein kinase signaling cascade
purine ribonucleotide metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process
purine-containing compound metabolic process
nucleotide metabolic process
nucleoside phosphate metabolic process
nucleobase-containing small molecule metabolic process
cell junction
viral process
regulation of cellular response to stress
regulation of MAPK cascade
symbiotic process
interspecies interaction between organisms
organophosphate metabolic process
apoptotic process
carbohydrate derivative metabolic process