MAOA

Entrez Summary: This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012].
UniProt Summary: Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

primary amine oxidase activity
dopamine catabolic process
catecholamine catabolic process
catechol-containing compound catabolic process
phenol-containing compound catabolic process
neurotransmitter catabolic process
dopamine metabolic process
catecholamine metabolic process
catechol-containing compound metabolic process
cellular biogenic amine metabolic process
cellular amine metabolic process
amine metabolic process
organic hydroxy compound catabolic process
phenol-containing compound metabolic process
neurotransmitter metabolic process
drug catabolic process
mitochondrial outer membrane
ammonium ion metabolic process
regulation of neurotransmitter levels
aromatic compound catabolic process
organic hydroxy compound metabolic process
organic cyclic compound catabolic process
drug metabolic process
cytokine-mediated signaling pathway
oxidation-reduction process
cellular response to cytokine stimulus
organonitrogen compound catabolic process
response to cytokine
mitochondrion
positive regulation of signal transduction
organic substance catabolic process
cellular catabolic process
positive regulation of cell communication
positive regulation of signaling