MAOB

Entrez Summary: The protein encoded by this gene belongs to the flavin monoamine oxidase family. It is a enzyme located in the mitochondrial outer membrane. It catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous sysytem and peripheral tissues. This protein preferentially degrades benzylamine and phenylethylamine. [provided by RefSeq, Jul 2008].
UniProt Summary: Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

negative regulation of serotonin secretion
response to aluminum ion
primary amine oxidase activity
positive regulation of dopamine metabolic process
positive regulation of catecholamine metabolic process
regulation of serotonin secretion
mitochondrial envelope
hydrogen peroxide biosynthetic process
dopamine catabolic process
positive regulation of cellular amine metabolic process
catechol-containing compound catabolic process
catecholamine catabolic process
response to selenium ion
phenol-containing compound catabolic process
antibiotic biosynthetic process
regulation of catecholamine metabolic process
regulation of dopamine metabolic process
response to corticosterone
neurotransmitter catabolic process
negative regulation of neurotransmitter transport
reactive oxygen species biosynthetic process
dopamine metabolic process
response to mineralocorticoid
hydrogen peroxide metabolic process
substantia nigra development
catecholamine metabolic process
catechol-containing compound metabolic process
flavin adenine dinucleotide binding
neural nucleus development
organic hydroxy compound catabolic process
electron transfer activity
regulation of cellular amine metabolic process
phenol-containing compound metabolic process
midbrain development
neurotransmitter metabolic process
antibiotic metabolic process
reactive oxygen species metabolic process
response to ethanol
regulation of neurotransmitter transport
response to glucocorticoid