MAP3K15

Gene Information

Official Symbol: MAP3K15
Official Name: mitogen-activated protein kinase kinase kinase 15
Aliases and Previous Symbols: N/A
Entrez ID: 389840
UniProt: Q6ZN16
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a member of the mitogen-activated protein kinase (MAPK) family. These family members function in a protein kinase signal transduction cascade, where an activated MAPK kinase kinase (MAP3K) phosphorylates and activates a specific MAPK kinase (MAP2K), which then activates a specific MAPK. This MAP3K protein plays an essential role in apoptotic cell death triggered by cellular stresses. [provided by RefSeq, Jul 2010].
UniProt Summary: May function in a signal transduction pathway that is activated by various cell stresses and leads to apoptosis. {ECO:0000269|PubMed:20362554}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6

Essentiality Rank: 8605
Expression level (log2 read counts): 2.61

Expression Distribution

Pkinase
Pkinase Tyr

MAP kinase kinase kinase activity
activation of MAPKK activity
protein kinase activity
positive regulation of MAP kinase activity
activation of protein kinase activity
positive regulation of protein serine/threonine kinase activity
regulation of MAP kinase activity
MAPK cascade
signal transduction by protein phosphorylation
regulation of protein serine/threonine kinase activity
positive regulation of protein kinase activity
positive regulation of MAPK cascade
positive regulation of kinase activity
positive regulation of transferase activity
regulation of MAPK cascade
regulation of protein kinase activity
regulation of kinase activity
protein phosphorylation
regulation of transferase activity
positive regulation of protein phosphorylation
positive regulation of intracellular signal transduction
positive regulation of phosphorylation
positive regulation of phosphate metabolic process
positive regulation of phosphorus metabolic process
positive regulation of protein modification process
phosphorylation
positive regulation of catalytic activity
regulation of protein phosphorylation
ATP binding
regulation of phosphorylation
positive regulation of cellular protein metabolic process
positive regulation of signal transduction
intracellular signal transduction
positive regulation of protein metabolic process
positive regulation of molecular function
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
positive regulation of cell communication
positive regulation of signaling
regulation of intracellular signal transduction