MAP3K9

Entrez Summary: N/A
UniProt Summary: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Plays also a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. {ECO:0000269|PubMed:11416147, ECO:0000269|PubMed:15610029}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

JUN kinase kinase kinase activity
activation of JNKK activity
MAP kinase kinase activity
activation of JUN kinase activity
activation of MAPKK activity
positive regulation of JUN kinase activity
JNK cascade
regulation of JUN kinase activity
stress-activated MAPK cascade
positive regulation of JNK cascade
stress-activated protein kinase signaling cascade
activation of MAPK activity
positive regulation of stress-activated MAPK cascade
positive regulation of stress-activated protein kinase signaling cascade
regulation of JNK cascade
protein autophosphorylation
regulation of stress-activated MAPK cascade
regulation of stress-activated protein kinase signaling cascade
positive regulation of MAP kinase activity
activation of protein kinase activity
positive regulation of protein serine/threonine kinase activity
regulation of MAP kinase activity
protein serine/threonine kinase activity
MAPK cascade
signal transduction by protein phosphorylation
cellular component
regulation of protein serine/threonine kinase activity
positive regulation of protein kinase activity
positive regulation of MAPK cascade
positive regulation of kinase activity
positive regulation of apoptotic process
positive regulation of programmed cell death
positive regulation of transferase activity
positive regulation of cell death
regulation of cellular response to stress
regulation of MAPK cascade
regulation of protein kinase activity
regulation of kinase activity
protein homodimerization activity
apoptotic process