MAP4K1
Gene Information
- Official Symbol: MAP4K1
- Official Name: mitogen-activated protein kinase kinase kinase kinase 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 11184
- UniProt: Q92918
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Pkinase |
| Pkinase Tyr |
| CNH |
GO Terms
| MAP kinase kinase kinase kinase activity |
| cellular response to phorbol 13-acetate 12-myristate |
| response to phorbol 13-acetate 12-myristate |
| activation of MAPKKK activity |
| activation of JUN kinase activity |
| positive regulation of JUN kinase activity |
| JNK cascade |
| cellular response to alcohol |
| regulation of JUN kinase activity |
| cellular response to ketone |
| response to antineoplastic agent |
| stress-activated MAPK cascade |
| positive regulation of JNK cascade |
| stress-activated protein kinase signaling cascade |
| activation of MAPK activity |
| positive regulation of stress-activated MAPK cascade |
| positive regulation of stress-activated protein kinase signaling cascade |
| peptidyl-serine phosphorylation |
| regulation of JNK cascade |
| response to ketone |
| protein autophosphorylation |
| peptidyl-serine modification |
| response to alcohol |
| regulation of stress-activated MAPK cascade |
| regulation of stress-activated protein kinase signaling cascade |
| protein kinase activity |
| positive regulation of MAP kinase activity |
| activation of protein kinase activity |
| positive regulation of protein serine/threonine kinase activity |
| regulation of MAP kinase activity |
| protein serine/threonine kinase activity |
| MAPK cascade |
| signal transduction by protein phosphorylation |
| cellular response to drug |
| regulation of protein serine/threonine kinase activity |
| cellular response to lipid |
| positive regulation of protein kinase activity |
| positive regulation of MAPK cascade |
| cell population proliferation |
| positive regulation of kinase activity |
| positive regulation of transferase activity |
| regulation of cellular response to stress |
| regulation of MAPK cascade |
| regulation of protein kinase activity |
| response to lipid |
| regulation of kinase activity |
| peptidyl-amino acid modification |
| protein phosphorylation |
| regulation of transferase activity |
| positive regulation of protein phosphorylation |
| response to drug |
| positive regulation of intracellular signal transduction |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| positive regulation of protein modification process |
| phosphorylation |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| regulation of response to stress |
| ATP binding |
| response to oxygen-containing compound |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| positive regulation of signal transduction |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 7822
- Expression level (log2 read counts): 5.61
Expression Distribution
MAP4K1 Expression in NALM6 Cells: 5.61
