MAP4K3

Entrez Summary: This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

MAP kinase kinase kinase kinase activity
activation of MAPKKK activity
JNK cascade
stress-activated MAPK cascade
stress-activated protein kinase signaling cascade
response to UV
protein kinase activity
positive regulation of MAP kinase activity
response to tumor necrosis factor
response to light stimulus
activation of protein kinase activity
positive regulation of protein serine/threonine kinase activity
regulation of MAP kinase activity
protein serine/threonine kinase activity
MAPK cascade
signal transduction by protein phosphorylation
response to radiation
regulation of protein serine/threonine kinase activity
positive regulation of protein kinase activity
positive regulation of MAPK cascade
positive regulation of kinase activity
positive regulation of transferase activity
regulation of MAPK cascade
regulation of protein kinase activity
regulation of kinase activity
protein phosphorylation
regulation of transferase activity
positive regulation of protein phosphorylation
positive regulation of intracellular signal transduction
positive regulation of phosphorylation
response to cytokine
positive regulation of phosphorus metabolic process
positive regulation of phosphate metabolic process
response to abiotic stimulus
positive regulation of protein modification process
phosphorylation
positive regulation of catalytic activity
regulation of protein phosphorylation
ATP binding
regulation of phosphorylation