MAPK15 [The Human Chemical-Genetic Interaction Map Project]

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======= MAPK15 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MAPK15
  * **<color #00a2e8>Official Name</color>**: mitogen-activated protein kinase 15
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=225689|225689]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TD08|Q8TD08]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MAPK15&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MAPK15|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618616|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  In vitro, phosphorylates MBP. {ECO:0000269|PubMed:11875070, ECO:0000269|PubMed:16484222}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase|
|Pkinase Tyr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of meiotic chromosome separation|
|positive regulation of metaphase/anaphase transition of meiosis I|
|regulation of metaphase/anaphase transition of meiosis I|
|positive regulation of metaphase/anaphase transition of meiotic cell cycle|
|regulation of metaphase/anaphase transition of meiotic cell cycle|
|regulation of meiotic chromosome separation|
|regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis|
|regulation of COPII vesicle coating|
|positive regulation of spindle assembly|
|regulation of vesicle targeting, to, from or within Golgi|
|positive regulation of meiotic cell cycle phase transition|
|dopamine uptake|
|regulation of meiotic cell cycle phase transition|
|catecholamine uptake|
|protein localization to ciliary transition zone|
|meiotic spindle|
|positive regulation of metaphase/anaphase transition of cell cycle|
|positive regulation of chromosome separation|
|dopamine transport|
|catecholamine transport|
|positive regulation of meiotic nuclear division|
|MAP kinase activity|
|regulation of ER to Golgi vesicle-mediated transport|
|positive regulation of telomere capping|
|monoamine transport|
|positive regulation of meiotic cell cycle|
|regulation of telomere capping|
|positive regulation of chromosome segregation|
|regulation of spindle assembly|
|regulation of meiotic nuclear division|
|positive regulation of telomere maintenance via telomerase|
|positive regulation of telomerase activity|
|positive regulation of telomere maintenance via telomere lengthening|
|regulation of spindle organization|
|protein localization to cilium|
|regulation of meiotic cell cycle|
|positive regulation of telomere maintenance|
|regulation of telomerase activity|
|ammonium transport|
|regulation of metaphase/anaphase transition of cell cycle|
|regulation of telomere maintenance via telomerase|
|endoplasmic reticulum organization|
|regulation of telomere maintenance via telomere lengthening|
|regulation of chromosome separation|
|positive regulation of nuclear division|
|positive regulation of DNA biosynthetic process|
|autophagosome|
|positive regulation of organelle assembly|
|positive regulation of reproductive process|
|regulation of sister chromatid segregation|
|regulation of cilium assembly|
|kinase activity|
|regulation of telomere maintenance|
|positive regulation of cell cycle phase transition|
|regulation of chromosome segregation|
|axoneme|
|regulation of DNA biosynthetic process|
|bicellular tight junction|
|SH3 domain binding|
|ciliary basal body|
|organic hydroxy compound transport|
|centriole|
|drug transport|
|regulation of reproductive process|
|cell-cell junction|
|positive regulation of chromosome organization|
|regulation of microtubule cytoskeleton organization|
|regulation of nuclear division|
|positive regulation of DNA metabolic process|
|protein autophosphorylation|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|regulation of organelle assembly|
|positive regulation of cytoskeleton organization|
|regulation of microtubule-based process|
|protein kinase activity|
|cytoplasmic vesicle|
|negative regulation of cell migration|
|negative regulation of cell motility|
|positive regulation of cell cycle process|
|negative regulation of cellular component movement|
|negative regulation of locomotion|
|regulation of autophagy|
|regulation of chromosome organization|
|regulation of intracellular transport|
|regulation of DNA metabolic process|
|MAPK cascade|
|positive regulation of cell cycle|
|signal transduction by protein phosphorylation|
|chromatin binding|
|endomembrane system organization|
|regulation of cell cycle phase transition|
|regulation of protein complex assembly|
|positive regulation of cellular component biogenesis|
|regulation of cytoskeleton organization|
|regulation of vesicle-mediated transport|
|positive regulation of organelle organization|
|positive regulation of transferase activity|
|import into cell|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|protein localization to organelle|
|regulation of cell cycle process|
|cellular response to DNA damage stimulus|
|cation transport|
|regulation of cellular catabolic process|
|regulation of cell migration|
|regulation of cell motility|
|regulation of cellular localization|
|positive regulation of cell population proliferation|
|regulation of cellular component biogenesis|
|protein phosphorylation|
|regulation of transferase activity|
|regulation of locomotion|
|Golgi apparatus|
|regulation of cellular component movement|
|regulation of catabolic process|
|response to drug|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|phosphorylation|
|regulation of organelle organization|
|ion transport|
|positive regulation of catalytic activity|
|ATP binding|
|cellular protein localization|
|cellular macromolecule localization|
|regulation of cell population proliferation|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of molecular function|
|nitrogen compound transport|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp360|Genistein 15μM R07 exp360]]|-1.87|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|-1.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4536
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MAPK15 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>