MAPK15
Gene Information
- Official Symbol: MAPK15
- Official Name: mitogen-activated protein kinase 15
- Aliases and Previous Symbols: N/A
- Entrez ID: 225689
- UniProt: Q8TD08
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: In vitro, phosphorylates MBP. {ECO:0000269|PubMed:11875070, ECO:0000269|PubMed:16484222}.
Pfam Domains GO Terms
Pfam Domains
| Pkinase |
| Pkinase Tyr |
GO Terms
| positive regulation of meiotic chromosome separation |
| positive regulation of metaphase/anaphase transition of meiosis I |
| regulation of metaphase/anaphase transition of meiosis I |
| positive regulation of metaphase/anaphase transition of meiotic cell cycle |
| regulation of metaphase/anaphase transition of meiotic cell cycle |
| regulation of meiotic chromosome separation |
| regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis |
| regulation of COPII vesicle coating |
| positive regulation of spindle assembly |
| regulation of vesicle targeting, to, from or within Golgi |
| positive regulation of meiotic cell cycle phase transition |
| dopamine uptake |
| regulation of meiotic cell cycle phase transition |
| catecholamine uptake |
| protein localization to ciliary transition zone |
| meiotic spindle |
| positive regulation of metaphase/anaphase transition of cell cycle |
| positive regulation of chromosome separation |
| dopamine transport |
| catecholamine transport |
| positive regulation of meiotic nuclear division |
| MAP kinase activity |
| regulation of ER to Golgi vesicle-mediated transport |
| positive regulation of telomere capping |
| monoamine transport |
| positive regulation of meiotic cell cycle |
| regulation of telomere capping |
| positive regulation of chromosome segregation |
| regulation of spindle assembly |
| regulation of meiotic nuclear division |
| positive regulation of telomere maintenance via telomerase |
| positive regulation of telomerase activity |
| positive regulation of telomere maintenance via telomere lengthening |
| regulation of spindle organization |
| protein localization to cilium |
| regulation of meiotic cell cycle |
| positive regulation of telomere maintenance |
| regulation of telomerase activity |
| ammonium transport |
| regulation of metaphase/anaphase transition of cell cycle |
| regulation of telomere maintenance via telomerase |
| endoplasmic reticulum organization |
| regulation of telomere maintenance via telomere lengthening |
| regulation of chromosome separation |
| positive regulation of nuclear division |
| positive regulation of DNA biosynthetic process |
| autophagosome |
| positive regulation of organelle assembly |
| positive regulation of reproductive process |
| regulation of sister chromatid segregation |
| regulation of cilium assembly |
| kinase activity |
| regulation of telomere maintenance |
| positive regulation of cell cycle phase transition |
| regulation of chromosome segregation |
| axoneme |
| regulation of DNA biosynthetic process |
| bicellular tight junction |
| SH3 domain binding |
| ciliary basal body |
| organic hydroxy compound transport |
| centriole |
| drug transport |
| regulation of reproductive process |
| cell-cell junction |
| positive regulation of chromosome organization |
| regulation of microtubule cytoskeleton organization |
| regulation of nuclear division |
| positive regulation of DNA metabolic process |
| protein autophosphorylation |
| regulation of plasma membrane bounded cell projection assembly |
| regulation of cell projection assembly |
| regulation of organelle assembly |
| positive regulation of cytoskeleton organization |
| regulation of microtubule-based process |
| protein kinase activity |
| cytoplasmic vesicle |
| negative regulation of cell migration |
| negative regulation of cell motility |
| positive regulation of cell cycle process |
| negative regulation of cellular component movement |
| negative regulation of locomotion |
| regulation of autophagy |
| regulation of chromosome organization |
| regulation of intracellular transport |
| regulation of DNA metabolic process |
| MAPK cascade |
| positive regulation of cell cycle |
| signal transduction by protein phosphorylation |
| chromatin binding |
| endomembrane system organization |
| regulation of cell cycle phase transition |
| regulation of protein complex assembly |
| positive regulation of cellular component biogenesis |
| regulation of cytoskeleton organization |
| regulation of vesicle-mediated transport |
| positive regulation of organelle organization |
| positive regulation of transferase activity |
| import into cell |
| regulation of plasma membrane bounded cell projection organization |
| regulation of cell projection organization |
| protein localization to organelle |
| regulation of cell cycle process |
| cellular response to DNA damage stimulus |
| cation transport |
| regulation of cellular catabolic process |
| regulation of cell migration |
| regulation of cell motility |
| regulation of cellular localization |
| positive regulation of cell population proliferation |
| regulation of cellular component biogenesis |
| protein phosphorylation |
| regulation of transferase activity |
| regulation of locomotion |
| Golgi apparatus |
| regulation of cellular component movement |
| regulation of catabolic process |
| response to drug |
| regulation of cell cycle |
| positive regulation of cellular component organization |
| phosphorylation |
| regulation of organelle organization |
| ion transport |
| positive regulation of catalytic activity |
| ATP binding |
| cellular protein localization |
| cellular macromolecule localization |
| regulation of cell population proliferation |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of molecular function |
| nitrogen compound transport |
| regulation of transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| extracellular region |
| positive regulation of cellular biosynthetic process |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Genistein 15μM R07 exp360 | -1.87 |
| ZLN024 50μM R08 exp538 | -1.8 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 4536
- Expression level (log2 read counts): -7.68
Expression Distribution
MAPK15 Expression in NALM6 Cells: -7.68
