MAPRE3

Entrez Summary: N/A
UniProt Summary: Plus-end tracking protein (+TIP) that binds to the plus- end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:28814570). Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (PubMed:28814570). May play a role in cell migration (By similarity). {ECO:0000250, ECO:0000269|PubMed:19255245, ECO:0000269|PubMed:28814570}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Hydroxychloroquine 30μM R08 exp490	-1.99
Rotenone 20μM R00 exp34	-1.77

EB1
CH

regulation of microtubule plus-end binding
positive regulation of microtubule plus-end binding
mitotic spindle astral microtubule end
protein localization to microtubule end
protein localization to microtubule plus-end
positive regulation of microtubule binding
regulation of microtubule binding
protein localization to microtubule
microtubule plus-end binding
microtubule plus-end
spindle midzone
positive regulation of cyclin-dependent protein serine/threonine kinase activity
protein localization to microtubule cytoskeleton
positive regulation of cyclin-dependent protein kinase activity
protein localization to cytoskeleton
regulation of microtubule polymerization
cytoplasmic microtubule
regulation of microtubule polymerization or depolymerization
positive regulation of protein binding
regulation of cyclin-dependent protein serine/threonine kinase activity
spindle assembly
regulation of cyclin-dependent protein kinase activity
spindle organization
microtubule organizing center
midbody
positive regulation of binding
protein C-terminus binding
regulation of microtubule cytoskeleton organization
regulation of protein binding
regulation of microtubule-based process
regulation of protein polymerization
microtubule binding
microtubule
positive regulation of protein serine/threonine kinase activity
regulation of supramolecular fiber organization
regulation of binding
positive regulation of cell cycle
regulation of protein complex assembly
protein kinase binding
microtubule cytoskeleton organization