MBL2 [The Human Chemical-Genetic Interaction Map Project]

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======= MBL2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MBL2
  * **<color #00a2e8>Official Name</color>**: mannose binding lectin 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4153|4153]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P11226|P11226]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MBL2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MBL2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/154545|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the soluble mannose-binding lectin or mannose-binding protein found in serum. The protein encoded belongs to the collectin family and is an important element in the innate immune system. The protein recognizes mannose and N-acetylglucosamine on many microorganisms, and is capable of activating the classical complement pathway. Deficiencies of this gene have been associated with susceptibility to autoimmune and infectious diseases. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Collagen|
|Lectin C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|opsonization|
|killing by host of symbiont cells|
|disruption by host of symbiont cells|
|complement activation, lectin pathway|
|killing of cells in other organism involved in symbiotic interaction|
|disruption of cells of other organism involved in symbiotic interaction|
|growth plate cartilage chondrocyte morphogenesis|
|chondrocyte morphogenesis|
|chondrocyte morphogenesis involved in endochondral bone morphogenesis|
|growth plate cartilage morphogenesis|
|mannose binding|
|growth plate cartilage chondrocyte differentiation|
|chondrocyte development involved in endochondral bone morphogenesis|
|cartilage morphogenesis|
|chondrocyte differentiation involved in endochondral bone morphogenesis|
|growth plate cartilage development|
|acute-phase response|
|endochondral bone growth|
|chondrocyte development|
|bone growth|
|cartilage development involved in endochondral bone morphogenesis|
|disruption of cells of other organism|
|killing of cells of other organism|
|collagen trimer|
|calcium-dependent protein binding|
|positive regulation of phagocytosis|
|acute inflammatory response|
|modification by host of symbiont morphology or physiology|
|endochondral bone morphogenesis|
|interaction with symbiont|
|chondrocyte differentiation|
|cell killing|
|defense response to Gram-positive bacterium|
|regulation of phagocytosis|
|organ growth|
|negative regulation of viral process|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|bone morphogenesis|
|modification of morphology or physiology of other organism|
|complement activation, classical pathway|
|humoral immune response mediated by circulating immunoglobulin|
|cartilage development|
|complement activation|
|bone development|
|regulation of viral process|
|immunoglobulin mediated immune response|
|B cell mediated immunity|
|negative regulation of multi-organism process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|connective tissue development|
|extracellular matrix|
|skeletal system morphogenesis|
|lymphocyte mediated immunity|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|phagocytosis|
|defense response to bacterium|
|signaling receptor binding|
|humoral immune response|
|collagen-containing extracellular matrix|
|response to oxidative stress|
|developmental growth|
|growth|
|skeletal system development|
|inflammatory response|
|regulation of vesicle-mediated transport|
|cell morphogenesis involved in differentiation|
|tissue morphogenesis|
|adaptive immune response|
|cell surface|
|activation of immune response|
|response to bacterium|
|calcium ion binding|
|cell morphogenesis|
|innate immune response|
|leukocyte mediated immunity|
|regulation of multi-organism process|
|symbiotic process|
|interspecies interaction between organisms|
|cellular component morphogenesis|
|positive regulation of immune response|
|defense response to other organism|
|animal organ morphogenesis|
|positive regulation of transport|
|immune effector process|
|regulation of immune response|
|positive regulation of immune system process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|extracellular space|
|cell development|
|regulation of immune system process|
|tissue development|
|regulation of transport|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10759
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MBL2 Expression in NALM6 Cells: -4.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>