MBL2

Entrez Summary: This gene encodes the soluble mannose-binding lectin or mannose-binding protein found in serum. The protein encoded belongs to the collectin family and is an important element in the innate immune system. The protein recognizes mannose and N-acetylglucosamine on many microorganisms, and is capable of activating the classical complement pathway. Deficiencies of this gene have been associated with susceptibility to autoimmune and infectious diseases. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Collagen
Lectin C

opsonization
killing by host of symbiont cells
disruption by host of symbiont cells
complement activation, lectin pathway
killing of cells in other organism involved in symbiotic interaction
disruption of cells of other organism involved in symbiotic interaction
growth plate cartilage chondrocyte morphogenesis
chondrocyte morphogenesis
chondrocyte morphogenesis involved in endochondral bone morphogenesis
growth plate cartilage morphogenesis
mannose binding
growth plate cartilage chondrocyte differentiation
chondrocyte development involved in endochondral bone morphogenesis
cartilage morphogenesis
chondrocyte differentiation involved in endochondral bone morphogenesis
growth plate cartilage development
acute-phase response
endochondral bone growth
chondrocyte development
bone growth
cartilage development involved in endochondral bone morphogenesis
disruption of cells of other organism
killing of cells of other organism
collagen trimer
calcium-dependent protein binding
positive regulation of phagocytosis
acute inflammatory response
modification by host of symbiont morphology or physiology
endochondral bone morphogenesis
interaction with symbiont
chondrocyte differentiation
cell killing
defense response to Gram-positive bacterium
regulation of phagocytosis
organ growth
negative regulation of viral process
modification of morphology or physiology of other organism involved in symbiotic interaction
bone morphogenesis
modification of morphology or physiology of other organism
complement activation, classical pathway