MCHR1

Entrez Summary: The protein encoded by this gene, a member of the G protein-coupled receptor family 1, is an integral plasma membrane protein which binds melanin-concentrating hormone. The encoded protein can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors, this protein does not seem to bind somatostatin. [provided by RefSeq, Jul 2008].
UniProt Summary: Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis. {ECO:0000269|PubMed:10421367}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
ML-792 0.2μM R08 exp505	1.81
Diepoxybutane 3μM R07 exp354	1.99

7TM GPCR Srsx
7tm 1

melanin-concentrating hormone receptor activity
hormone binding
neuropeptide receptor activity
neuropeptide binding
non-motile cilium
peptide binding
ciliary membrane
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
feeding behavior
neuropeptide signaling pathway
positive regulation of calcium ion transport
protein C-terminus binding
cilium
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
regulation of calcium ion transport
positive regulation of ion transport
positive regulation of cytosolic calcium ion concentration
regulation of cytosolic calcium ion concentration
signaling receptor binding
regulation of metal ion transport
generation of precursor metabolites and energy
cellular calcium ion homeostasis
calcium ion homeostasis
cellular divalent inorganic cation homeostasis
divalent inorganic cation homeostasis
cellular metal ion homeostasis
behavior
metal ion homeostasis
cellular cation homeostasis
cellular ion homeostasis
regulation of ion transport
cation homeostasis
inorganic ion homeostasis
G protein-coupled receptor activity
cellular chemical homeostasis
ion homeostasis
cellular homeostasis
positive regulation of transport
chemical homeostasis