MCOLN2

Gene Information

Official Symbol: MCOLN2
Official Name: mucolipin 2
Aliases and Previous Symbols: N/A
Entrez ID: 255231
UniProt: Q8IZK6
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Nonselective cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca(2+)- permeable cation channel with inwardly rectifying activity (PubMed:19940139, PubMed:19885840). May activate ARF6 and be involved in the trafficking of GPI-anchored cargo proteins to the cell surface via the ARF6-regulated recycling pathway (PubMed:17662026). May play a role in immune processes. In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells (By similarity). In the innate immune response, may play a role in the regulation of chemokine secretion and macrophage migration (By similarity). Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events (PubMed:19885840). {ECO:0000250|UniProtKB:Q8K595, ECO:0000269|PubMed:17662026, ECO:0000269|PubMed:19885840, ECO:0000269|PubMed:19940139, ECO:0000305}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14949
Expression level (log2 read counts): 2.15

Expression Distribution

positive regulation of macrophage inflammatory protein 1 alpha production
chemokine (C-X-C motif) ligand 2 production
chemokine (C-C motif) ligand 2 secretion
chemokine secretion
NAADP-sensitive calcium-release channel activity
positive regulation of chemokine (C-C motif) ligand 5 production
regulation of macrophage inflammatory protein 1 alpha production
regulation of chemokine (C-C motif) ligand 5 production
chemokine production
positive regulation of chemokine (C-X-C motif) ligand 2 production
positive regulation of monocyte chemotactic protein-1 production
regulation of chemokine (C-X-C motif) ligand 2 production
regulation of monocyte chemotactic protein-1 production
macrophage migration
cytokine secretion
release of sequestered calcium ion into cytosol
positive regulation of chemokine production
negative regulation of sequestering of calcium ion
calcium ion transmembrane import into cytosol
calcium ion transport into cytosol
regulation of chemokine production
recycling endosome membrane
cytosolic calcium ion transport
neutrophil migration
granulocyte migration
late endosome membrane
regulation of sequestering of calcium ion
myeloid leukocyte migration
cytokine production
protein secretion
establishment of protein localization to extracellular region
protein localization to extracellular region
peptide secretion
calcium ion transmembrane transport
calcium ion transport
positive regulation of cytosolic calcium ion concentration
divalent metal ion transport
lysosomal membrane
divalent inorganic cation transport
regulation of cytosolic calcium ion concentration