MDFIC

Gene Information

Official Symbol: MDFIC
Official Name: MyoD family inhibitor domain containing
Aliases and Previous Symbols: N/A
Entrez ID: 29969
UniProt: Q9P1T7
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene product is a member of a family of proteins characterized by a specific cysteine-rich C-terminal domain, which is involved in transcriptional regulation of viral genome expression. Alternative translation initiation from an upstream non-AUG (GUG), and an in-frame, downstream AUG codon, results in the production of two isoforms, p40 and p32, respectively, which have different subcellular localization; p32 is mainly found in the cytoplasm, whereas p40 is targeted to the nucleolus. Both isoforms have transcriptional regulatory activity that is attributable to the cysteine-rich C-terminal domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009].
UniProt Summary: Acts as a transcriptional activator or repressor. Inhibits the transcriptional activation of Zic family proteins ZIC1, ZIC2 and ZIC3. Retains nuclear Zic proteins ZIC1, ZIC2 and ZIC3 in the cytoplasm. Modulates the expression from both cellular and viral promoters. Down-regulates Tat-dependent transcription of the human immunodeficiency virus type 1 (HIV-1) LTR by interacting with HIV-1 Tat and Rev and impairing their nuclear import, probably by rendering the NLS domains inaccessible to importin- beta. Also stimulates activation of human T-cell leukemia virus type I (HTLV-I) LTR. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways. {ECO:0000269|PubMed:10671520, ECO:0000269|PubMed:12192039, ECO:0000269|PubMed:12944466, ECO:0000269|PubMed:16260749, ECO:0000269|Ref.6}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14208
Expression level (log2 read counts): 1.8

Expression Distribution

Tat protein binding
negative regulation of protein import into nucleus
negative regulation of protein import
negative regulation of nucleocytoplasmic transport
negative regulation of protein localization to nucleus
cyclin binding
activation of JUN kinase activity
positive regulation of viral transcription
negative regulation of intracellular protein transport
regulation of protein import into nucleus
regulation of protein import
negative regulation of intracellular transport
regulation of viral transcription
positive regulation of JUN kinase activity
JNK cascade
regulation of JUN kinase activity
stress-activated MAPK cascade
regulation of nucleocytoplasmic transport
positive regulation of viral process
negative regulation of cellular protein localization
regulation of protein localization to nucleus
positive regulation of JNK cascade
stress-activated protein kinase signaling cascade
activation of MAPK activity
positive regulation of stress-activated MAPK cascade
positive regulation of stress-activated protein kinase signaling cascade
negative regulation of protein transport
regulation of JNK cascade
negative regulation of establishment of protein localization
regulation of viral process
regulation of symbiosis, encompassing mutualism through parasitism
regulation of intracellular protein transport
regulation of stress-activated MAPK cascade
regulation of stress-activated protein kinase signaling cascade
positive regulation of MAP kinase activity
activation of protein kinase activity
transcription factor binding
positive regulation of protein serine/threonine kinase activity
regulation of MAP kinase activity
regulation of intracellular transport