MESDC2 [The Human Chemical-Genetic Interaction Map Project]

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======= MESDC2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MESD
  * **<color #00a2e8>Official Name</color>**: mesoderm development LRP chaperone
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23184|23184]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14696|Q14696]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MESDC2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MESDC2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607783|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Chaperone specifically assisting the folding of beta- propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction. Plays an essential role in neuromuscular junction (NMJ) formation by promoting cell- surface expression of LRP4 (By similarity). May regulate phagocytosis of apoptotic retinal pigment epithelium (RPE) cells (By similarity). {ECO:0000250|UniProtKB:Q9ERE7, ECO:0000269|PubMed:15014448, ECO:0000269|PubMed:17488095}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Mesd|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of skeletal muscle acetylcholine-gated channel clustering|
|positive regulation of postsynaptic membrane organization|
|positive regulation of neuromuscular junction development|
|regulation of skeletal muscle acetylcholine-gated channel clustering|
|positive regulation of receptor clustering|
|regulation of neuromuscular junction development|
|regulation of receptor clustering|
|regulation of postsynaptic membrane organization|
|low-density lipoprotein particle receptor binding|
|protein localization to cell surface|
|regulation of postsynapse organization|
|positive regulation of protein localization to membrane|
|mesoderm development|
|regulation of protein localization to membrane|
|regulation of synapse organization|
|regulation of synapse structure or activity|
|protein folding|
|positive regulation of cellular protein localization|
|phagocytosis|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|cellular component|
|regulation of cellular protein localization|
|molecular function|
|regulation of cellular localization|
|endoplasmic reticulum|
|regulation of protein localization|
|identical protein binding|
|cell-cell signaling|
|positive regulation of cellular component organization|
|cellular protein localization|
|cellular macromolecule localization|
|tissue development|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|-2.06|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|1.97|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|2.28|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8560
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MESDC2 Expression in NALM6 Cells: 6.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>