MESDC2

Entrez Summary: N/A
UniProt Summary: Chaperone specifically assisting the folding of beta- propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction. Plays an essential role in neuromuscular junction (NMJ) formation by promoting cell- surface expression of LRP4 (By similarity). May regulate phagocytosis of apoptotic retinal pigment epithelium (RPE) cells (By similarity). {ECO:0000250|UniProtKB:Q9ERE7, ECO:0000269|PubMed:15014448, ECO:0000269|PubMed:17488095}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	-2.06
Bafilomycin-A1 0.009μM R08 exp454	1.97
CoCl2 18μM R07 exp346	2.28

positive regulation of skeletal muscle acetylcholine-gated channel clustering
positive regulation of postsynaptic membrane organization
positive regulation of neuromuscular junction development
regulation of skeletal muscle acetylcholine-gated channel clustering
positive regulation of receptor clustering
regulation of neuromuscular junction development
regulation of receptor clustering
regulation of postsynaptic membrane organization
low-density lipoprotein particle receptor binding
protein localization to cell surface
regulation of postsynapse organization
positive regulation of protein localization to membrane
mesoderm development
regulation of protein localization to membrane
regulation of synapse organization
regulation of synapse structure or activity
protein folding
positive regulation of cellular protein localization
phagocytosis
Wnt signaling pathway
cell-cell signaling by wnt
cell surface receptor signaling pathway involved in cell-cell signaling
cellular component
regulation of cellular protein localization
molecular function
regulation of cellular localization
endoplasmic reticulum
regulation of protein localization
identical protein binding
cell-cell signaling
positive regulation of cellular component organization
cellular protein localization
cellular macromolecule localization
tissue development
vesicle-mediated transport