MFI2 [The Human Chemical-Genetic Interaction Map Project]

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======= MFI2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MELTF
  * **<color #00a2e8>Official Name</color>**: melanotransferrin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4241|4241]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P08582|P08582]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MFI2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MFI2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/155750|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc. {ECO:0000269|PubMed:7556058}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Transferrin|
|Phosphonate-bd|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of plasminogen activation|
|positive regulation of extracellular matrix disassembly|
|negative regulation of substrate adhesion-dependent cell spreading|
|regulation of plasminogen activation|
|regulation of extracellular matrix disassembly|
|positive regulation of extracellular matrix organization|
|positive regulation of protein processing|
|positive regulation of protein maturation|
|anchored component of plasma membrane|
|regulation of extracellular matrix organization|
|regulation of substrate adhesion-dependent cell spreading|
|negative regulation of cell-substrate adhesion|
|regulation of protein processing|
|regulation of protein maturation|
|iron ion transport|
|iron ion homeostasis|
|negative regulation of cell morphogenesis involved in differentiation|
|transition metal ion transport|
|transition metal ion homeostasis|
|iron ion binding|
|regulation of cell-substrate adhesion|
|negative regulation of cell adhesion|
|endoplasmic reticulum lumen|
|regulation of cell morphogenesis involved in differentiation|
|negative regulation of cell development|
|positive regulation of proteolysis|
|post-translational protein modification|
|regulation of cell growth|
|regulation of cell morphogenesis|
|cell surface|
|metal ion homeostasis|
|metal ion transport|
|regulation of growth|
|regulation of cell adhesion|
|negative regulation of cellular component organization|
|cation homeostasis|
|negative regulation of cell differentiation|
|inorganic ion homeostasis|
|regulation of proteolysis|
|ion homeostasis|
|cation transport|
|regulation of cell development|
|negative regulation of developmental process|
|regulation of anatomical structure morphogenesis|
|chemical homeostasis|
|positive regulation of cellular component organization|
|ion transport|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|homeostatic process|
|positive regulation of protein metabolic process|
|regulation of cell differentiation|
|extracellular region|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|-2.12|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|1.83|
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|1.87|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|2.45|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4355
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.86 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MFI2 Expression in NALM6 Cells: 2.86'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>