MFI2

Entrez Summary: N/A
UniProt Summary: Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc. {ECO:0000269|PubMed:7556058}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Transferrin
Phosphonate-bd

positive regulation of plasminogen activation
positive regulation of extracellular matrix disassembly
negative regulation of substrate adhesion-dependent cell spreading
regulation of plasminogen activation
regulation of extracellular matrix disassembly
positive regulation of extracellular matrix organization
positive regulation of protein processing
positive regulation of protein maturation
anchored component of plasma membrane
regulation of extracellular matrix organization
regulation of substrate adhesion-dependent cell spreading
negative regulation of cell-substrate adhesion
regulation of protein processing
regulation of protein maturation
iron ion transport
iron ion homeostasis
negative regulation of cell morphogenesis involved in differentiation
transition metal ion transport
transition metal ion homeostasis
iron ion binding
regulation of cell-substrate adhesion
negative regulation of cell adhesion
endoplasmic reticulum lumen
regulation of cell morphogenesis involved in differentiation
negative regulation of cell development
positive regulation of proteolysis
post-translational protein modification
regulation of cell growth
regulation of cell morphogenesis
cell surface
metal ion homeostasis
metal ion transport
regulation of growth
regulation of cell adhesion
negative regulation of cellular component organization
cation homeostasis
negative regulation of cell differentiation
inorganic ion homeostasis
regulation of proteolysis
ion homeostasis