MFNG

Entrez Summary: N/A
UniProt Summary: Glycosyltransferase that initiates the elongation of O- linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules (PubMed:10935626). Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1 (By similarity). {ECO:0000250|UniProtKB:O09008, ECO:0000269|PubMed:10935626}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity
protein O-linked fucosylation
marginal zone B cell differentiation
mature B cell differentiation involved in immune response
fucosylation
acetylglucosaminyltransferase activity
mature B cell differentiation
blastocyst formation
B cell activation involved in immune response
positive regulation of Notch signaling pathway
integral component of Golgi membrane
positive regulation of protein binding
blastocyst development
regulation of Notch signaling pathway
B cell differentiation
protein O-linked glycosylation
lymphocyte activation involved in immune response
B cell activation
positive regulation of binding
regulation of protein binding
lymphocyte differentiation
protein glycosylation
macromolecule glycosylation
glycosylation
glycoprotein biosynthetic process
leukocyte differentiation
in utero embryonic development
regulation of binding
lymphocyte activation
glycoprotein metabolic process
pattern specification process
hemopoiesis
hematopoietic or lymphoid organ development
carbohydrate derivative biosynthetic process
leukocyte activation involved in immune response
cell activation involved in immune response
chordate embryonic development
immune system development
embryo development ending in birth or egg hatching
anatomical structure formation involved in morphogenesis