MIF
Gene Information
- Official Symbol: MIF
- Official Name: macrophage migration inhibitory factor
- Aliases and Previous Symbols: N/A
- Entrez ID: 4282
- UniProt: P14174
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. [provided by RefSeq, Jul 2008].
- UniProt Summary: Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti- inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity. {ECO:0000269|PubMed:15908412, ECO:0000269|PubMed:17443469, ECO:0000269|PubMed:23776208}.
Pfam Domains GO Terms
Pfam Domains
| MIF |
GO Terms
| positive regulation of prostaglandin secretion involved in immune response |
| phenylpyruvate tautomerase activity |
| dopachrome isomerase activity |
| negative regulation of mature B cell apoptotic process |
| regulation of mature B cell apoptotic process |
| positive regulation of arachidonic acid secretion |
| negative regulation of macrophage chemotaxis |
| positive regulation of lipopolysaccharide-mediated signaling pathway |
| regulation of arachidonic acid secretion |
| positive regulation of chemokine (C-X-C motif) ligand 2 production |
| positive regulation of protein kinase A signaling |
| positive regulation of prostaglandin secretion |
| negative regulation of macrophage migration |
| regulation of chemokine (C-X-C motif) ligand 2 production |
| cytokine receptor binding |
| regulation of prostaglandin secretion |
| negative regulation of B cell apoptotic process |
| negative regulation of DNA damage response, signal transduction by p53 class mediator |
| negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
| positive regulation of icosanoid secretion |
| negative regulation of myeloid cell apoptotic process |
| regulation of B cell apoptotic process |
| negative regulation of leukocyte chemotaxis |
| positive regulation of fatty acid transport |
| regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
| positive regulation of myeloid leukocyte cytokine production involved in immune response |
| prostaglandin biosynthetic process |
| regulation of icosanoid secretion |
| prostanoid biosynthetic process |
| regulation of protein kinase A signaling |
| negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator |
| negative regulation of cell cycle arrest |
| negative regulation of cell aging |
| regulation of lipopolysaccharide-mediated signaling pathway |
| regulation of macrophage chemotaxis |
| regulation of fatty acid transport |
| negative regulation of lymphocyte apoptotic process |
| regulation of myeloid cell apoptotic process |
| regulation of intrinsic apoptotic signaling pathway by p53 class mediator |
| negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage |
| protein homotrimerization |
| negative regulation of signal transduction by p53 class mediator |
| prostaglandin metabolic process |
| regulation of DNA damage response, signal transduction by p53 class mediator |
| prostanoid metabolic process |
| positive regulation of organic acid transport |
| chemoattractant activity |
| regulation of macrophage migration |
| regulation of intrinsic apoptotic signaling pathway in response to DNA damage |
| positive regulation of B cell proliferation |
| unsaturated fatty acid biosynthetic process |
| negative regulation of leukocyte migration |
| icosanoid biosynthetic process |
| negative regulation of leukocyte apoptotic process |
| interleukin-12-mediated signaling pathway |
| positive chemotaxis |
| regulation of cell aging |
| cellular response to interleukin-12 |
| response to interleukin-12 |
| positive regulation of fibroblast proliferation |
| positive regulation of anion transport |
| regulation of macrophage activation |
| regulation of lymphocyte apoptotic process |
| protein trimerization |
| positive regulation of cytokine production involved in immune response |
| positive regulation of chemokine production |
| negative regulation of chemotaxis |
| regulation of organic acid transport |
| positive regulation of lipid transport |
| regulation of B cell proliferation |
| cell aging |
| regulation of chemokine production |
| DNA damage response, signal transduction by p53 class mediator |
| negative regulation of response to DNA damage stimulus |
| positive regulation of lipid localization |
| regulation of fibroblast proliferation |
| regulation of leukocyte apoptotic process |
| regulation of cytokine production involved in immune response |
| positive regulation of tumor necrosis factor production |
| positive regulation of tumor necrosis factor superfamily cytokine production |
| fatty acid derivative biosynthetic process |
| negative regulation of intrinsic apoptotic signaling pathway |
| regulation of anion transport |
| positive regulation of production of molecular mediator of immune response |
| protease binding |
| signal transduction in response to DNA damage |
| positive regulation of peptidyl-serine phosphorylation |
| unsaturated fatty acid metabolic process |
| regulation of cell cycle arrest |
| regulation of lipid transport |
| icosanoid metabolic process |
| regulation of leukocyte chemotaxis |
| secretory granule lumen |
| fatty acid biosynthetic process |
| signal transduction by p53 class mediator |
| ficolin-1-rich granule lumen |
| positive regulation of lymphocyte proliferation |
| positive regulation of mononuclear cell proliferation |
| positive regulation of leukocyte proliferation |
| regulation of peptidyl-serine phosphorylation |
| regulation of lipid localization |
| positive regulation of cytokine secretion |
| regulation of production of molecular mediator of immune response |
| vesicle |
| regulation of tumor necrosis factor production |
| regulation of tumor necrosis factor superfamily cytokine production |
| regulation of intrinsic apoptotic signaling pathway |
| positive regulation of B cell activation |
| fatty acid derivative metabolic process |
| cytokine activity |
| regulation of signal transduction by p53 class mediator |
| monocarboxylic acid biosynthetic process |
| positive regulation of peptidyl-tyrosine phosphorylation |
| regulation of leukocyte migration |
| regulation of cytokine secretion |
| regulation of B cell activation |
| regulation of lymphocyte proliferation |
| regulation of mononuclear cell proliferation |
| positive regulation of ERK1 and ERK2 cascade |
| regulation of chemotaxis |
| positive regulation of immune effector process |
| regulation of response to DNA damage stimulus |
| regulation of leukocyte proliferation |
| negative regulation of apoptotic signaling pathway |
| regulation of peptidyl-tyrosine phosphorylation |
| negative regulation of cell migration |
| positive regulation of MAP kinase activity |
| positive regulation of protein secretion |
| negative regulation of cell motility |
| positive regulation of ion transport |
| aging |
| positive regulation of peptide secretion |
| regulation of ERK1 and ERK2 cascade |
| carboxylic acid biosynthetic process |
| organic acid biosynthetic process |
| negative regulation of cellular component movement |
| negative regulation of locomotion |
| fatty acid metabolic process |
| negative regulation of cell cycle process |
| signaling receptor binding |
| positive regulation of protein serine/threonine kinase activity |
| protein homooligomerization |
| regulation of MAP kinase activity |
| positive regulation of lymphocyte activation |
| positive regulation of response to biotic stimulus |
| negative regulation of response to external stimulus |
| positive regulation of cell cycle |
| leukocyte migration |
| regulation of apoptotic signaling pathway |
| positive regulation of leukocyte activation |
| positive regulation of secretion by cell |
| positive regulation of cell activation |
| positive regulation of protein transport |
| positive regulation of secretion |
| negative regulation of immune system process |
| positive regulation of cytokine production |
| positive regulation of establishment of protein localization |
| regulation of protein secretion |
| regulation of immune effector process |
| neutrophil degranulation |
| neutrophil activation involved in immune response |
| regulation of peptide secretion |
| inflammatory response |
| neutrophil mediated immunity |
| neutrophil activation |
| granulocyte activation |
| negative regulation of intracellular signal transduction |
| positive regulation of multi-organism process |
| leukocyte degranulation |
| regulation of lymphocyte activation |
| regulation of protein serine/threonine kinase activity |
| myeloid leukocyte mediated immunity |
| protein complex oligomerization |
| regulation of response to biotic stimulus |
| myeloid cell activation involved in immune response |
| monocarboxylic acid metabolic process |
| positive regulation of protein kinase activity |
| positive regulation of MAPK cascade |
| chemotaxis |
| taxis |
| cell population proliferation |
| negative regulation of cell cycle |
| positive regulation of kinase activity |
| lipid biosynthetic process |
| myeloid leukocyte activation |
| small molecule biosynthetic process |
| regulation of leukocyte activation |
| positive regulation of response to external stimulus |
| cell surface |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| regulation of cell activation |
| positive regulation of transferase activity |
| cytokine-mediated signaling pathway |
| regulation of cytokine production |
| regulation of ion transport |
| regulated exocytosis |
| regulation of protein transport |
| regulation of cellular response to stress |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of cell cycle process |
| regulation of MAPK cascade |
| innate immune response |
| leukocyte mediated immunity |
| regulation of multi-organism process |
| cellular response to DNA damage stimulus |
| exocytosis |
| regulation of protein kinase activity |
| regulation of secretion |
| regulation of cell migration |
| positive regulation of immune response |
| regulation of kinase activity |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| carboxylic acid metabolic process |
| regulation of cell motility |
| positive regulation of cell population proliferation |
| leukocyte activation |
| negative regulation of developmental process |
| defense response to other organism |
| cellular lipid metabolic process |
| cell migration |
| regulation of transferase activity |
| regulation of locomotion |
| positive regulation of transport |
| regulation of cellular component movement |
| negative regulation of cell death |
| oxoacid metabolic process |
| secretion by cell |
| cellular response to cytokine stimulus |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| organic acid metabolic process |
| regulation of protein localization |
| negative regulation of cellular protein metabolic process |
| export from cell |
| positive regulation of phosphorylation |
| identical protein binding |
| cell activation |
| cell motility |
| localization of cell |
| immune effector process |
| regulation of response to external stimulus |
| response to cytokine |
| negative regulation of protein metabolic process |
| secretion |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| regulation of immune response |
| positive regulation of immune system process |
| regulation of cell cycle |
| lipid metabolic process |
| positive regulation of protein modification process |
| negative regulation of signal transduction |
| response to other organism |
| response to external biotic stimulus |
| locomotion |
| response to biotic stimulus |
| defense response |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| regulation of response to stress |
| regulation of apoptotic process |
| movement of cell or subcellular component |
| protein-containing complex assembly |
| regulation of programmed cell death |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| positive regulation of signal transduction |
| regulation of immune system process |
| regulation of cell death |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| positive regulation of multicellular organismal process |
| small molecule metabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| protein-containing complex subunit organization |
| regulation of transport |
| immune response |
| extracellular region |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 12648
- Expression level (log2 read counts): 6.68
Expression Distribution
MIF Expression in NALM6 Cells: 6.68
