MIPEP [The Human Chemical-Genetic Interaction Map Project]

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======= MIPEP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MIPEP
  * **<color #00a2e8>Official Name</color>**: mitochondrial intermediate peptidase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4285|4285]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99797|Q99797]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MIPEP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MIPEP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602241|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The product of this gene performs the final step in processing a specific class of nuclear-encoded proteins targeted to the mitochondrial matrix or inner membrane. This protein is primarily involved in the maturation of oxidative phosphorylation (OXPHOS)-related proteins. This gene may contribute to the functional effects of frataxin deficiency and the clinical manifestations of Friedreich ataxia. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Cleaves proteins, imported into the mitochondrion, to their mature size.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Peptidase M3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein processing involved in protein targeting to mitochondrion|
|mitochondrial protein processing|
|protein targeting to mitochondrion|
|establishment of protein localization to mitochondrion|
|protein localization to mitochondrion|
|metalloendopeptidase activity|
|protein processing|
|mitochondrial transport|
|protein maturation|
|protein targeting|
|mitochondrial matrix|
|establishment of protein localization to organelle|
|mitochondrion organization|
|peptide metabolic process|
|protein localization to organelle|
|cellular amide metabolic process|
|intracellular protein transport|
|mitochondrion|
|proteolysis|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|1.7|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|1.71|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.72|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|1.76|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.8|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|1.86|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.91|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|1.94|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|1.96|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.1|
|[[:results:exp359|FK-506 30μM R07 exp359]]|2.22|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|2.23|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.33|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|2.65|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.81|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|5.28|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|5.48|
|[[:results:exp532|TIC10 10μM R08 exp532]]|6.25|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:i:iba57|IBA57]]|0.6|
|[[:human genes:c:clpp|CLPP]]|0.568|
|[[:human genes:r:rbfa|RBFA]]|0.559|
|[[:human genes:m:mrps34|MRPS34]]|0.558|
|[[:human genes:m:mrpl23|MRPL23]]|0.557|
|[[:human genes:g:glrx5|GLRX5]]|0.556|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.554|
|[[:human genes:t:tomm20|TOMM20]]|0.552|
|[[:human genes:m:mrpl21|MRPL21]]|0.55|
|[[:human genes:m:mtg1|MTG1]]|0.549|
|[[:human genes:n:nars2|NARS2]]|0.546|
|[[:human genes:c:c12orf65|C12orf65]]|0.541|
|[[:human genes:m:mrps5|MRPS5]]|0.54|
|[[:human genes:n:ndufb11|NDUFB11]]|0.537|
|[[:human genes:e:ecsit|ECSIT]]|0.53|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.528|
|[[:human genes:n:ndufa3|NDUFA3]]|0.522|
|[[:human genes:q:qrsl1|QRSL1]]|0.519|
|[[:human genes:m:mcat|MCAT]]|0.516|
|[[:human genes:n:ndufb6|NDUFB6]]|0.513|
|[[:human genes:y:yars2|YARS2]]|0.509|
|[[:human genes:m:mrps21|MRPS21]]|0.509|
|[[:human genes:a:aars2|AARS2]]|0.508|
|[[:human genes:t:tars2|TARS2]]|0.503|
|[[:human genes:m:mrps12|MRPS12]]|0.502|
|[[:human genes:a:acad9|ACAD9]]|0.5|
|[[:human genes:e:ears2|EARS2]]|0.499|
|[[:human genes:m:mettl17|METTL17]]|0.496|
|[[:human genes:r:rpusd4|RPUSD4]]|0.496|
|[[:human genes:m:mrps16|MRPS16]]|0.495|
|[[:human genes:m:mrpl12|MRPL12]]|0.494|
|[[:human genes:m:mtg2|MTG2]]|0.494|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.491|
|[[:human genes:m:mrps26|MRPS26]]|0.491|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.49|
|[[:human genes:c:coa3|COA3]]|0.489|
|[[:human genes:l:lars2|LARS2]]|0.487|
|[[:human genes:g:gfm2|GFM2]]|0.484|
|[[:human genes:g:grsf1|GRSF1]]|0.483|
|[[:human genes:f:ftsj2|FTSJ2]]|0.483|
|[[:human genes:t:tpk1|TPK1]]|0.481|
|[[:human genes:m:mrps10|MRPS10]]|0.481|
|[[:human genes:g:gfm1|GFM1]]|0.479|
|[[:human genes:p:pet112|PET112]]|0.478|
|[[:human genes:n:ndufb9|NDUFB9]]|0.478|
|[[:human genes:w:wars2|WARS2]]|0.477|
|[[:human genes:p:polg|POLG]]|0.476|
|[[:human genes:f:fastkd5|FASTKD5]]|0.476|
|[[:human genes:n:ndufs2|NDUFS2]]|0.474|
|[[:human genes:f:fars2|FARS2]]|0.473|
|[[:human genes:m:mrpl47|MRPL47]]|0.472|
|[[:human genes:i:isca2|ISCA2]]|0.472|
|[[:human genes:m:mrpl53|MRPL53]]|0.471|
|[[:human genes:c:c17orf89|C17orf89]]|0.47|
|[[:human genes:s:selrc1|SELRC1]]|0.47|
|[[:human genes:m:mrpl45|MRPL45]]|0.468|
|[[:human genes:m:mrps6|MRPS6]]|0.468|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.464|
|[[:human genes:p:polg2|POLG2]]|0.46|
|[[:human genes:n:nubpl|NUBPL]]|0.459|
|[[:human genes:m:mrps18a|MRPS18A]]|0.458|
|[[:human genes:m:mrp63|MRP63]]|0.458|
|[[:human genes:c:chchd1|CHCHD1]]|0.458|
|[[:human genes:m:mto1|MTO1]]|0.458|
|[[:human genes:v:vars2|VARS2]]|0.457|
|[[:human genes:n:nfu1|NFU1]]|0.457|
|[[:human genes:t:tmem242|TMEM242]]|0.452|
|[[:human genes:n:ndufb5|NDUFB5]]|0.451|
|[[:human genes:t:tefm|TEFM]]|0.45|
|[[:human genes:n:ndufa11|NDUFA11]]|0.449|
|[[:human genes:a:atp5sl|ATP5SL]]|0.448|
|[[:human genes:s:sco2|SCO2]]|0.447|
|[[:human genes:g:gatc|GATC]]|0.446|
|[[:human genes:n:ndufa1|NDUFA1]]|0.446|
|[[:human genes:r:rars2|RARS2]]|0.446|
|[[:human genes:m:mrps14|MRPS14]]|0.443|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.442|
|[[:human genes:t:trub2|TRUB2]]|0.442|
|[[:human genes:n:ndufa2|NDUFA2]]|0.442|
|[[:human genes:m:mrps2|MRPS2]]|0.441|
|[[:human genes:h:hmbs|HMBS]]|0.441|
|[[:human genes:n:ndufa8|NDUFA8]]|0.44|
|[[:human genes:m:mrps25|MRPS25]]|0.437|
|[[:human genes:d:dap3|DAP3]]|0.436|
|[[:human genes:w:wbscr16|WBSCR16]]|0.435|
|[[:human genes:c:coq2|COQ2]]|0.434|
|[[:human genes:s:ssbp1|SSBP1]]|0.434|
|[[:human genes:m:mrps17|MRPS17]]|0.434|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.433|
|[[:human genes:m:mrps24|MRPS24]]|0.432|
|[[:human genes:m:mrps22|MRPS22]]|0.432|
|[[:human genes:h:hars2|HARS2]]|0.431|
|[[:human genes:n:ndufb2|NDUFB2]]|0.431|
|[[:human genes:b:bcs1l|BCS1L]]|0.431|
|[[:human genes:r:rpusd3|RPUSD3]]|0.43|
|[[:human genes:i:ict1|ICT1]]|0.43|
|[[:human genes:m:mettl1|METTL1]]|0.429|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.428|
|[[:human genes:n:ndufs7|NDUFS7]]|0.427|
|[[:human genes:t:tufm|TUFM]]|0.426|
|[[:human genes:s:sars2|SARS2]]|0.426|
|[[:human genes:n:nsun4|NSUN4]]|0.426|
|[[:human genes:p:pars2|PARS2]]|0.425|
|[[:human genes:m:mrps35|MRPS35]]|0.424|
|[[:human genes:f:foxred1|FOXRED1]]|0.421|
|[[:human genes:m:mrpl43|MRPL43]]|0.421|
|[[:human genes:m:mars2|MARS2]]|0.421|
|[[:human genes:d:dars2|DARS2]]|0.421|
|[[:human genes:p:pet117|PET117]]|0.42|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.419|
|[[:human genes:m:mterfd2|MTERFD2]]|0.419|
|[[:human genes:f:fastkd2|FASTKD2]]|0.418|
|[[:human genes:d:ddx28|DDX28]]|0.416|
|[[:human genes:m:mrpl18|MRPL18]]|0.415|
|[[:human genes:c:cox16|COX16]]|0.415|
|[[:human genes:m:mrps18b|MRPS18B]]|0.415|
|[[:human genes:m:mrps9|MRPS9]]|0.414|
|[[:human genes:m:mrpl13|MRPL13]]|0.413|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.413|
|[[:human genes:n:ndufc2|NDUFC2]]|0.412|
|[[:human genes:n:ndufb10|NDUFB10]]|0.411|
|[[:human genes:p:pgm3|PGM3]]|0.411|
|[[:human genes:p:polrmt|POLRMT]]|0.409|
|[[:human genes:m:mrpl15|MRPL15]]|0.408|
|[[:human genes:c:cox11|COX11]]|0.407|
|[[:human genes:m:mrps33|MRPS33]]|0.407|
|[[:human genes:t:trmt61a|TRMT61A]]|0.405|
|[[:human genes:c:coa6|COA6]]|0.404|
|[[:human genes:i:isca1|ISCA1]]|0.401|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 40/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|2/28|
|bone|1/26|
|breast|1/33|
|central nervous system|4/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|1/21|
|liver|4/20|
|lung|6/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|2/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 760
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.31 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MIPEP Expression in NALM6 Cells: 4.31'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>