MLLT3

Gene Information

Official Symbol: MLLT3
Official Name: MLLT3 super elongation complex subunit
Aliases and Previous Symbols: N/A
Entrez ID: 4300
UniProt: P42568
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:20159561, PubMed:20471948, PubMed:25417107, PubMed:27105114, PubMed:27545619). Specifically recognizes and binds acylated histone H3, with a marked preference for histone H3 that is crotonylated (PubMed:25417107, PubMed:27105114, PubMed:27545619). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25417107, PubMed:27105114, PubMed:27545619). Recognizes and binds histone H3 crotonylated at 'Lys-9' (H3K9cr), and with slightly lower affinity histone H3 crotonylated at 'Lys-18' (H3K18cr) (PubMed:27105114). Also recognizes and binds histone H3 acetylated at 'Lys-9' (H3K9ac), but with lower affinity than crotonylated histone H3 (PubMed:25417107, PubMed:27105114). In the SEC complex, MLLT3 is required to recruit the complex to crotonylated histones (PubMed:27105114, PubMed:27545619). {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:25417107, ECO:0000269|PubMed:27105114, ECO:0000269|PubMed:27545619}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 19058
Expression level (log2 read counts): 1.06

Expression Distribution

modification-dependent protein binding
positive regulation of Wnt signaling pathway, planar cell polarity pathway
positive regulation of non-canonical Wnt signaling pathway
regulation of Wnt signaling pathway, planar cell polarity pathway
segment specification
lysine-acetylated histone binding
regulation of non-canonical Wnt signaling pathway
transcription elongation factor complex
transcription elongation from RNA polymerase II promoter
DNA-templated transcription, elongation
segmentation
regulation of establishment of planar polarity
chromosome
histone binding
negative regulation of canonical Wnt signaling pathway
positive regulation of Wnt signaling pathway
regulation of morphogenesis of an epithelium
negative regulation of Wnt signaling pathway
anterior/posterior pattern specification
regulation of animal organ morphogenesis
regulation of canonical Wnt signaling pathway
regionalization
regulation of Wnt signaling pathway
chromatin binding
pattern specification process
transcription by RNA polymerase II
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
regulation of anatomical structure morphogenesis
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
negative regulation of signal transduction
organic cyclic compound biosynthetic process
negative regulation of cell communication
negative regulation of signaling
positive regulation of transcription, DNA-templated
DNA-binding transcription factor activity, RNA polymerase II-specific
negative regulation of response to stimulus