MLLT4

Entrez Summary: This gene encodes a multi-domain protein involved in signaling and organization of cell junctions during embryogenesis. It has also been identified as the fusion partner of acute lymphoblastic leukemia (ALL-1) gene, involved in acute myeloid leukemias with t(6;11)(q27;q23) translocation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, however, not all have been fully characterized.[provided by RefSeq, May 2011].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 3/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Centrinone 0.5μM R07 exp343	-1.85
Cabazitaxel 0.001μM R05 exp223	-1.71

tight junction
positive regulation of cell-cell adhesion mediated by cadherin
pore complex
Ras GTPase binding
establishment of endothelial intestinal barrier
regulation of cell-cell adhesion mediated by cadherin
pore complex assembly
cell-cell contact zone
cell-cell adhesion mediated by cadherin
establishment of endothelial barrier
bicellular tight junction assembly
tight junction assembly
tight junction organization
apical junction assembly
endothelial cell development
establishment of protein localization to plasma membrane
cell adhesion molecule binding
endothelial cell differentiation
adherens junction organization
endothelium development
cell-cell adherens junction
cell-cell junction assembly
cell-cell junction organization
cell junction assembly
cell-cell junction
protein localization to plasma membrane
protein C-terminus binding
epithelial cell development
actin filament binding
cell junction organization
protein localization to cell periphery
positive regulation of cell-cell adhesion
negative regulation of cell migration
establishment of protein localization to membrane
negative regulation of cell motility
negative regulation of cellular component movement
cadherin binding
negative regulation of locomotion
regulation of cell-cell adhesion
nuclear speck