MMP24 [The Human Chemical-Genetic Interaction Map Project]

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======= MMP24 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MMP24
  * **<color #00a2e8>Official Name</color>**: matrix metallopeptidase 24
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10893|10893]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y5R2|Q9Y5R2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MMP24&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MMP24|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604871|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence. Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia. Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate their quiescence. May play a role in axonal growth. Able to activate progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Peptidase M10|
|DUF3377|
|PG binding 1|
|Hemopexin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|detection of temperature stimulus involved in sensory perception of pain|
|detection of temperature stimulus involved in sensory perception|
|detection of temperature stimulus|
|sensory perception of temperature stimulus|
|neuronal stem cell population maintenance|
|cell-cell adhesion mediated by cadherin|
|collagen catabolic process|
|enzyme activator activity|
|collagen metabolic process|
|sensory perception of pain|
|trans-Golgi network membrane|
|metalloendopeptidase activity|
|detection of external stimulus|
|detection of abiotic stimulus|
|stem cell population maintenance|
|maintenance of cell number|
|glial cell differentiation|
|response to temperature stimulus|
|gliogenesis|
|extracellular matrix|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|cadherin binding|
|extracellular matrix organization|
|extracellular structure organization|
|cell-cell adhesion|
|detection of stimulus involved in sensory perception|
|detection of stimulus|
|zinc ion binding|
|cell adhesion|
|biological adhesion|
|sensory perception|
|response to abiotic stimulus|
|proteolysis|
|nervous system process|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|extracellular space|
|neurogenesis|
|positive regulation of molecular function|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|1.9|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3784
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MMP24 Expression in NALM6 Cells: 1.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>