MMP24

Entrez Summary: N/A
UniProt Summary: Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence. Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia. Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate their quiescence. May play a role in axonal growth. Able to activate progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

detection of temperature stimulus involved in sensory perception of pain
detection of temperature stimulus involved in sensory perception
detection of temperature stimulus
sensory perception of temperature stimulus
neuronal stem cell population maintenance
cell-cell adhesion mediated by cadherin
collagen catabolic process
enzyme activator activity
collagen metabolic process
sensory perception of pain
trans-Golgi network membrane
metalloendopeptidase activity
detection of external stimulus
detection of abiotic stimulus
stem cell population maintenance
maintenance of cell number
glial cell differentiation
response to temperature stimulus
gliogenesis
extracellular matrix
cell-cell adhesion via plasma-membrane adhesion molecules
cadherin binding
extracellular matrix organization
extracellular structure organization
cell-cell adhesion
detection of stimulus involved in sensory perception
detection of stimulus
zinc ion binding
cell adhesion
biological adhesion
sensory perception
response to abiotic stimulus
proteolysis
nervous system process
integral component of plasma membrane
positive regulation of catalytic activity
extracellular space
neurogenesis
positive regulation of molecular function
system process