MOB4 [The Human Chemical-Genetic Interaction Map Project]

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======= MOB4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MOB4
  * **<color #00a2e8>Official Name</color>**: MOB family member 4, phocein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=25843|25843]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y3A3|Q9Y3A3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MOB4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MOB4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609361|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in membrane trafficking, specifically in membrane budding reactions. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Mob1 phocein|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Golgi cisterna membrane|
|perinuclear region of cytoplasm|
|Golgi apparatus|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-1.84|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|-1.83|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-1.8|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|-1.75|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|-1.73|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-1.7|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|-1.7|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|1.78|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|2.39|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:strip1|STRIP1]]|0.553|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 52/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|3/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|4/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|1/21|
|liver|2/20|
|lung|4/75|
|lymphocyte|0/16|
|ovary|8/26|
|pancreas|2/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|3/9|
|thyroid|1/2|
|upper aerodigestive|1/22|
|urinary tract|5/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2141
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MOB4 Expression in NALM6 Cells: 4.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>