MPV17L

Gene Information

Official Symbol: MPV17L
Official Name: MPV17 mitochondrial inner membrane protein like
Aliases and Previous Symbols: N/A
Entrez ID: 255027
UniProt: Q2QL34
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Isoform 1 participates in reactive oxygen species metablism by up- or down-regulation of the genes of antioxidant enzymes. {ECO:0000269|PubMed:16631601}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18365
Expression level (log2 read counts): 6.84

Expression Distribution

negative regulation of hydrogen peroxide biosynthetic process
regulation of hydrogen peroxide biosynthetic process
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
negative regulation of cofactor metabolic process
negative regulation of hydrogen peroxide metabolic process
regulation of hydrogen peroxide metabolic process
negative regulation of reactive oxygen species biosynthetic process
regulation of cofactor metabolic process
regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
negative regulation of mitochondrion organization
negative regulation of reactive oxygen species metabolic process
peroxisomal membrane
regulation of mitochondrial membrane permeability
regulation of membrane permeability
regulation of reactive oxygen species biosynthetic process
mitochondrial membrane organization
regulation of reactive oxygen species metabolic process
regulation of mitochondrion organization
mitochondrial transport
negative regulation of apoptotic signaling pathway
negative regulation of organelle organization
regulation of apoptotic signaling pathway
mitochondrion organization
negative regulation of transport
intracellular membrane-bounded organelle
negative regulation of cellular component organization
molecular function
membrane organization
negative regulation of apoptotic process
negative regulation of programmed cell death
negative regulation of cell death
mitochondrion
negative regulation of signal transduction
regulation of organelle organization
negative regulation of cell communication
negative regulation of signaling
negative regulation of cellular biosynthetic process
regulation of apoptotic process
negative regulation of biosynthetic process
regulation of programmed cell death