MRC1

Entrez Summary: The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.[provided by RefSeq, Sep 2015].
UniProt Summary: Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. (Microbial infection) Acts as a receptor for Dengue virus envelope protein E. {ECO:0000269|PubMed:18266465}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cargo receptor activity
mannose binding
cellular response to interleukin-4
response to interleukin-4
virus receptor activity
viral entry into host cell
entry into host
entry into host cell
transmembrane signaling receptor activity
interaction with host
cellular response to interferon-gamma
response to interferon-gamma
cellular response to lipopolysaccharide
cellular response to molecule of bacterial origin
viral life cycle
endosome membrane
cellular response to biotic stimulus
receptor-mediated endocytosis
response to lipopolysaccharide
response to molecule of bacterial origin
cellular response to lipid
endocytosis
cell surface
import into cell
response to bacterium
viral process
innate immune response
symbiotic process
interspecies interaction between organisms
response to lipid
defense response to other organism
cellular response to cytokine stimulus
cellular response to oxygen-containing compound
response to cytokine
response to other organism
response to external biotic stimulus
response to biotic stimulus
defense response
integral component of plasma membrane
response to oxygen-containing compound