MSRB1

Entrez Summary: N/A
UniProt Summary: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post- translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)- sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages. {ECO:0000250|UniProtKB:Q9JLC3}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
TRAIL 50ng/ml R00 exp36	1.79
Vinblastine 0.002μM R01 exp60	2.08

methionine-R-sulfoxide reductase activity
L-methionine-(R)-S-oxide reductase activity
peptide-methionine (R)-S-oxide reductase activity
protein repair
actin filament polymerization
actin polymerization or depolymerization
protein polymerization
actin cytoskeleton
actin filament organization
actin binding
cellular component
supramolecular fiber organization
actin cytoskeleton organization
actin filament-based process
innate immune response
zinc ion binding
cellular protein-containing complex assembly
defense response to other organism
oxidation-reduction process
cytoskeleton organization
response to other organism
response to external biotic stimulus
response to biotic stimulus
defense response
protein-containing complex assembly
protein-containing complex subunit organization
immune response