MT1G

Entrez Summary: N/A
UniProt Summary: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	1/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

monocyte activation
stress response to copper ion
detoxification of copper ion
mononuclear cell differentiation
monocyte differentiation
detoxification of inorganic compound
stress response to metal ion
cellular response to zinc ion
cellular response to copper ion
cellular zinc ion homeostasis
zinc ion homeostasis
cellular response to cadmium ion
cellular response to vascular endothelial growth factor stimulus
response to copper ion
response to zinc ion
response to cadmium ion
cellular transition metal ion homeostasis
myeloid leukocyte differentiation
detoxification
transition metal ion homeostasis
cellular response to metal ion
cellular response to inorganic substance
myeloid cell differentiation
negative regulation of growth
leukocyte differentiation
response to metal ion
cellular divalent inorganic cation homeostasis
divalent inorganic cation homeostasis
cellular response to growth factor stimulus
response to toxic substance
response to growth factor
response to inorganic substance
cellular metal ion homeostasis
hemopoiesis
myeloid leukocyte activation
hematopoietic or lymphoid organ development
metal ion homeostasis
cellular cation homeostasis
cellular ion homeostasis
immune system development