MT1HL1

Entrez Summary: N/A
UniProt Summary: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

detoxification of copper ion
stress response to copper ion
stress response to metal ion
detoxification of inorganic compound
cellular response to zinc ion
cellular response to copper ion
cellular zinc ion homeostasis
zinc ion homeostasis
cellular response to cadmium ion
response to copper ion
response to zinc ion
response to cadmium ion
cellular transition metal ion homeostasis
detoxification
transition metal ion homeostasis
cellular response to metal ion
cellular response to inorganic substance
response to metal ion
cellular divalent inorganic cation homeostasis
divalent inorganic cation homeostasis
response to toxic substance
response to inorganic substance
cellular metal ion homeostasis
metal ion homeostasis
cellular cation homeostasis
cellular ion homeostasis
cation homeostasis
inorganic ion homeostasis
cellular chemical homeostasis
ion homeostasis
cellular homeostasis
chemical homeostasis
homeostatic process