MT3 [The Human Chemical-Genetic Interaction Map Project]

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======= MT3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MT3
  * **<color #00a2e8>Official Name</color>**: metallothionein 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4504|4504]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P25713|P25713]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MT3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MT3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/139255|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Metallothio|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of lysosomal membrane permeability|
|regulation of lysosomal membrane permeability|
|negative regulation of hydrogen peroxide catabolic process|
|positive regulation of oxygen metabolic process|
|astrocyte end-foot|
|cadmium ion homeostasis|
|lysosomal membrane organization|
|regulation of oxygen metabolic process|
|regulation of hydrogen peroxide catabolic process|
|cadmium ion binding|
|positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress|
|negative regulation of cofactor metabolic process|
|positive regulation of necrotic cell death|
|negative regulation of hydrogen peroxide metabolic process|
|leptin-mediated signaling pathway|
|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|
|removal of superoxide radicals|
|sterol catabolic process|
|cholesterol catabolic process|
|regulation of protein glycosylation|
|positive regulation of vascular endothelial growth factor receptor signaling pathway|
|cellular response to superoxide|
|cellular response to oxygen radical|
|cellular response to nitric oxide|
|detoxification of copper ion|
|negative regulation of necrotic cell death|
|stress response to copper ion|
|response to superoxide|
|detoxification of inorganic compound|
|cellular response to leptin stimulus|
|stress response to metal ion|
|antioxidant activity|
|response to oxygen radical|
|inclusion body|
|cellular response to reactive nitrogen species|
|regulation of response to food|
|response to nitric oxide|
|regulation of hydrogen peroxide metabolic process|
|positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus|
|response to leptin|
|positive regulation of membrane permeability|
|cellular response to zinc ion|
|negative regulation of oxidoreductase activity|
|regulation of response to extracellular stimulus|
|regulation of response to nutrient levels|
|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|
|protein kinase activator activity|
|zinc ion transport|
|steroid catabolic process|
|ERK1 and ERK2 cascade|
|regulation of necrotic cell death|
|cellular response to copper ion|
|positive regulation of transcription from RNA polymerase II promoter in response to stress|
|regulation of vascular endothelial growth factor receptor signaling pathway|
|activation of protein kinase B activity|
|cellular zinc ion homeostasis|
|astrocyte development|
|regulation of cofactor metabolic process|
|zinc ion homeostasis|
|cellular response to cadmium ion|
|protein kinase B signaling|
|superoxide metabolic process|
|regulation of glycoprotein biosynthetic process|
|negative regulation of axon extension|
|ribosome|
|regulation of glycoprotein metabolic process|
|response to copper ion|
|response to bronchodilator|
|astrocyte differentiation|
|response to zinc ion|
|negative regulation of reactive oxygen species metabolic process|
|alcohol catabolic process|
|copper ion binding|
|drug binding|
|lytic vacuole organization|
|lysosome organization|
|rough endoplasmic reticulum|
|energy reserve metabolic process|
|response to cadmium ion|
|negative regulation of axonogenesis|
|organic hydroxy compound catabolic process|
|regulation of membrane permeability|
|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|negative regulation of autophagy|
|cellular oxidant detoxification|
|negative regulation of cysteine-type endopeptidase activity|
|regulation of oxidoreductase activity|
|regulation of axon extension|
|negative regulation of cell morphogenesis involved in differentiation|
|cellular detoxification|
|negative regulation of developmental growth|
|glial cell development|
|cellular transition metal ion homeostasis|
|regulation of extent of cell growth|
|reactive oxygen species metabolic process|
|cholesterol metabolic process|
|synaptic vesicle|
|regulation of transcription from RNA polymerase II promoter in response to stress|
|transition metal ion transport|
|regulation of DNA-templated transcription in response to stress|
|detoxification|
|secondary alcohol metabolic process|
|vacuole organization|
|cellular response to reactive oxygen species|
|transition metal ion homeostasis|
|sterol metabolic process|
|negative regulation of neuron apoptotic process|
|dendritic spine|
|negative regulation of neuron projection development|
|mitochondrial outer membrane|
|glial cell differentiation|
|protein stabilization|
|regulation of reactive oxygen species metabolic process|
|negative regulation of cell projection organization|
|regulation of cell size|
|negative regulation of cell growth|
|regulation of axonogenesis|
|cellular response to hypoxia|
|cellular response to metal ion|
|response to reactive oxygen species|
|cellular lipid catabolic process|
|cellular response to decreased oxygen levels|
|regulation of neuron apoptotic process|
|negative regulation of neuron death|
|positive regulation of ERK1 and ERK2 cascade|
|cellular response to toxic substance|
|gliogenesis|
|cellular response to oxygen levels|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|cellular response to inorganic substance|
|negative regulation of neuron differentiation|
|energy derivation by oxidation of organic compounds|
|cellular response to oxidative stress|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of growth|
|negative regulation of endopeptidase activity|
|postsynaptic density|
|negative regulation of cellular catabolic process|
|negative regulation of peptidase activity|
|steroid metabolic process|
|regulation of cellular response to growth factor stimulus|
|regulation of protein stability|
|negative regulation of neurogenesis|
|regulation of ERK1 and ERK2 cascade|
|axon|
|divalent metal ion transport|
|lipid catabolic process|
|divalent inorganic cation transport|
|regulation of cell morphogenesis involved in differentiation|
|negative regulation of catabolic process|
|regulation of neuron death|
|negative regulation of nervous system development|
|microtubule|
|alcohol metabolic process|
|activation of protein kinase activity|
|regulation of developmental growth|
|regulation of autophagy|
|negative regulation of cell development|
|response to hypoxia|
|negative regulation of proteolysis|
|response to decreased oxygen levels|
|histone modification|
|response to metal ion|
|MAPK cascade|
|covalent chromatin modification|
|regulation of cellular component size|
|response to oxygen levels|
|response to oxidative stress|
|signal transduction by protein phosphorylation|
|cellular response to drug|
|regulation of endopeptidase activity|
|regulation of cell growth|
|generation of precursor metabolites and energy|
|small molecule catabolic process|
|regulation of peptidase activity|
|negative regulation of hydrolase activity|
|organic hydroxy compound metabolic process|
|cellular divalent inorganic cation homeostasis|
|organic cyclic compound catabolic process|
|divalent inorganic cation homeostasis|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|response to toxic substance|
|regulation of anatomical structure size|
|positive regulation of protein kinase activity|
|response to inorganic substance|
|positive regulation of MAPK cascade|
|cellular metal ion homeostasis|
|positive regulation of kinase activity|
|cellular response to hormone stimulus|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|positive regulation of transferase activity|
|regulation of neuron differentiation|
|cellular response to nitrogen compound|
|regulation of growth|
|cytokine-mediated signaling pathway|
|regulation of plasma membrane bounded cell projection organization|
|perinuclear region of cytoplasm|
|positive regulation of cell death|
|chromatin organization|
|negative regulation of cellular component organization|
|cation homeostasis|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|inorganic ion homeostasis|
|regulation of proteolysis|
|brain development|
|cellular chemical homeostasis|
|regulation of MAPK cascade|
|head development|
|ion homeostasis|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of neurogenesis|
|cation transport|
|regulation of cellular catabolic process|
|zinc ion binding|
|membrane organization|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|response to hormone|
|apoptotic process|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|cellular lipid metabolic process|
|oxidation-reduction process|
|protein phosphorylation|
|regulation of transferase activity|
|central nervous system development|
|regulation of catabolic process|
|negative regulation of cell death|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|response to drug|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|chromosome organization|
|response to nitrogen compound|
|cell death|
|regulation of response to external stimulus|
|response to cytokine|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of molecular function|
|response to abiotic stimulus|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|lipid metabolic process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of hydrolase activity|
|phosphorylation|
|negative regulation of RNA metabolic process|
|ion transport|
|negative regulation of cellular macromolecule biosynthetic process|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|small molecule metabolic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|-2.94|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|-2.2|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|-2.15|
|[[:results:exp139|Nicotinamide Riboside 100μM R03 exp139]]|-1.98|
|[[:results:exp116|AICAR 240μM R03 exp116]]|-1.95|
|[[:results:exp136|MS094 2μM R03 exp136]]|-1.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:ruvbl2|RUVBL2]]|0.412|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15216
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MT3 Expression in NALM6 Cells: -4.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>