MTAP

Entrez Summary: This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine. The encoded enzyme is deficient in many cancers because this gene and the tumor suppressor p16 gene are co-deleted. Multiple alternatively spliced transcript variants have been described for this gene, but their full-length natures remain unknown. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

S-methyl-5-thioadenosine phosphorylase activity
nicotinamide riboside catabolic process
pyridine nucleoside catabolic process
nicotinamide riboside metabolic process
pyridine nucleoside metabolic process
phosphorylase activity
purine ribonucleoside salvage
L-methionine salvage from methylthioadenosine
amino acid salvage
pyridine-containing compound catabolic process
L-methionine salvage
L-methionine biosynthetic process
methionine biosynthetic process
purine-containing compound salvage
nucleoside salvage
methionine metabolic process
sulfur amino acid biosynthetic process
purine ribonucleoside biosynthetic process
ribonucleoside biosynthetic process
purine nucleoside biosynthetic process
aspartate family amino acid biosynthetic process
cellular metabolic compound salvage
nucleoside catabolic process
nucleoside biosynthetic process
sulfur amino acid metabolic process
pyridine-containing compound metabolic process
glycosyl compound biosynthetic process
glycosyl compound catabolic process
interleukin-12-mediated signaling pathway
cellular response to interleukin-12
response to interleukin-12
nucleobase-containing small molecule catabolic process
aspartate family amino acid metabolic process
purine ribonucleoside metabolic process
purine nucleoside metabolic process
alpha-amino acid biosynthetic process
ribonucleoside metabolic process
cellular amino acid biosynthetic process
nucleobase-containing small molecule biosynthetic process
nucleoside metabolic process