MTHFD2L

Gene Information

Official Symbol: MTHFD2L
Official Name: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like
Aliases and Previous Symbols: N/A
Entrez ID: 441024
UniProt: Q9H903
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12520
Expression level (log2 read counts): 4.78

Expression Distribution

THF DHG CYH C
THF DHG CYH

histidine biosynthetic process
methylenetetrahydrofolate dehydrogenase (NAD+) activity
aromatic amino acid family biosynthetic process
methenyltetrahydrofolate cyclohydrolase activity
methylenetetrahydrofolate dehydrogenase (NADP+) activity
10-formyltetrahydrofolate metabolic process
histidine metabolic process
tetrahydrofolate interconversion
imidazole-containing compound metabolic process
methionine biosynthetic process
methionine metabolic process
sulfur amino acid biosynthetic process
tetrahydrofolate metabolic process
folic acid metabolic process
aspartate family amino acid biosynthetic process
one-carbon metabolic process
folic acid-containing compound metabolic process
pteridine-containing compound metabolic process
aromatic amino acid family metabolic process
sulfur amino acid metabolic process
aspartate family amino acid metabolic process
alpha-amino acid biosynthetic process
cellular amino acid biosynthetic process
water-soluble vitamin metabolic process
dicarboxylic acid metabolic process
vitamin metabolic process
purine nucleotide biosynthetic process
purine-containing compound biosynthetic process
sulfur compound biosynthetic process
cellular modified amino acid metabolic process
alpha-amino acid metabolic process
nucleotide biosynthetic process
nucleoside phosphate biosynthetic process
coenzyme metabolic process
carboxylic acid biosynthetic process
organic acid biosynthetic process
cellular amino acid metabolic process
purine nucleotide metabolic process
sulfur compound metabolic process
purine-containing compound metabolic process