MTTP

Entrez Summary: MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia. [provided by RefSeq, Jul 2008].
UniProt Summary: Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces (PubMed:23475612, PubMed:8939939, PubMed:26224785, PubMed:25108285, PubMed:22236406). Required for the secretion of plasma lipoproteins that contain apolipoprotein B (PubMed:23475612, PubMed:8939939, PubMed:26224785). {ECO:0000269|PubMed:22236406, ECO:0000269|PubMed:23475612, ECO:0000269|PubMed:25108285, ECO:0000269|PubMed:26224785, ECO:0000269|PubMed:8939939}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

phospholipid transfer activity
triglyceride transfer activity
acylglycerol transport
triglyceride transport
ceramide 1-phosphate transport
ceramide 1-phosphate transfer activity
chylomicron assembly
very-low-density lipoprotein particle assembly
ceramide transport
phospholipid transporter activity
plasma lipoprotein particle assembly
lipid transporter activity
protein-lipid complex assembly
plasma lipoprotein particle organization
protein-lipid complex subunit organization
regulation of plasma lipoprotein particle levels
cholesterol homeostasis
sterol homeostasis
phospholipid transport
lipoprotein metabolic process
organophosphate ester transport
lipid homeostasis
lipid binding
protein secretion
establishment of protein localization to extracellular region
protein localization to extracellular region
peptide secretion
basolateral plasma membrane
receptor complex
lipid transport
endoplasmic reticulum lumen
lipid localization
extracellular structure organization
organic anion transport
protein heterodimerization activity
anion transport
Golgi apparatus
secretion by cell
endoplasmic reticulum
export from cell