MUC12

Gene Information

Official Symbol: MUC12
Official Name: mucin 12, cell surface associated
Aliases and Previous Symbols: N/A
Entrez ID: 10071
UniProt: Q9UKN1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes an integral membrane glycoprotein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces and have been implicated in epithelial renewal and differentiation. These glycoproteins also play a role in intracellular signaling. This protein is expressed on the apical membrane surface of epithelial cells that line the mucosal surfaces of many different tissues including the colon, pancreas, prostate, and uterus. The expression of this gene is downregulated in colorectal cancer tissue. [provided by RefSeq, Apr 2017].
UniProt Summary: Involved in epithelial cell protection, adhesion modulation, and signaling. May be involved in epithelial cell growth regulation. Stimulated by both cytokine TNF-alpha and TGF- beta in intestinal epithelium. {ECO:0000269|PubMed:17058067}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6437
Expression level (log2 read counts): -6.6

Expression Distribution

O-glycan processing
Golgi lumen
protein O-linked glycosylation
stimulatory C-type lectin receptor signaling pathway
innate immune response activating cell surface receptor signaling pathway
innate immune response-activating signal transduction
activation of innate immune response
protein glycosylation
macromolecule glycosylation
glycosylation
glycoprotein biosynthetic process
positive regulation of innate immune response
positive regulation of response to biotic stimulus
glycoprotein metabolic process
regulation of cell growth
immune response-activating cell surface receptor signaling pathway
regulation of innate immune response
positive regulation of defense response
immune response-regulating cell surface receptor signaling pathway
positive regulation of multi-organism process
regulation of response to biotic stimulus
immune response-activating signal transduction
immune response-regulating signaling pathway
positive regulation of response to external stimulus
carbohydrate derivative biosynthetic process
activation of immune response
regulation of growth
molecular function
regulation of defense response
regulation of multi-organism process
positive regulation of immune response
carbohydrate derivative metabolic process
regulation of response to external stimulus
regulation of immune response
positive regulation of immune system process
integral component of plasma membrane
organonitrogen compound biosynthetic process
regulation of response to stress
regulation of immune system process
cellular macromolecule biosynthetic process