MUC21

Gene Information

Official Symbol: MUC21
Official Name: mucin 21, cell surface associated
Aliases and Previous Symbols: N/A
Entrez ID: 394263
UniProt: Q5SSG8
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a large membrane-bound glycoprotein which is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. The encoded protein contains an N-terminal signal sequence, an extracellular mucin domain, a stem domain, a transmembrane domain, and a C-terminal cytoplasmic tail domain. The mucin domain contains O-glycosylation sites and is polymorphic with isoforms containing a variable number of nonidentical proline-, threonine-, and serine-rich tandem repeats of 15 amino acids each. The aberrent expression of this gene is associated with lung adenocarcinoma. [provided by RefSeq, May 2017].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 11387
Expression level (log2 read counts): -0.12

Expression Distribution

O-glycan processing
Golgi lumen
protein O-linked glycosylation
stimulatory C-type lectin receptor signaling pathway
innate immune response activating cell surface receptor signaling pathway
negative regulation of cell-cell adhesion
innate immune response-activating signal transduction
protein glycosylation
macromolecule glycosylation
activation of innate immune response
glycosylation
negative regulation of cell adhesion
glycoprotein biosynthetic process
positive regulation of innate immune response
positive regulation of response to biotic stimulus
glycoprotein metabolic process
regulation of cell-cell adhesion
immune response-activating cell surface receptor signaling pathway
regulation of innate immune response
positive regulation of defense response
immune response-regulating cell surface receptor signaling pathway
positive regulation of multi-organism process
regulation of response to biotic stimulus
immune response-activating signal transduction
immune response-regulating signaling pathway
positive regulation of response to external stimulus
carbohydrate derivative biosynthetic process
activation of immune response
regulation of cell adhesion
regulation of defense response
regulation of multi-organism process
positive regulation of immune response
carbohydrate derivative metabolic process
regulation of response to external stimulus
positive regulation of immune system process
regulation of immune response
organonitrogen compound biosynthetic process
regulation of response to stress
regulation of immune system process
cellular macromolecule biosynthetic process