MYH6 [The Human Chemical-Genetic Interaction Map Project]

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======= MYH6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MYH6
  * **<color #00a2e8>Official Name</color>**: myosin heavy chain 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4624|4624]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P13533|P13533]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MYH6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MYH6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/160710|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Cardiac muscle myosin is a hexamer consisting of two heavy chain subunits, two light chain subunits, and two regulatory subunits. This gene encodes the alpha heavy chain subunit of cardiac myosin. The gene is located approximately 4kb downstream of the gene encoding the beta heavy chain subunit of cardiac myosin. Mutations in this gene cause familial hypertrophic cardiomyopathy and atrial septal defect 3. [provided by RefSeq, Feb 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Muscle contraction.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Myosin tail 1|
|Myosin head|
|Myosin N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|visceral muscle development|
|myosin phosphatase activity|
|atrial cardiac muscle tissue morphogenesis|
|atrial cardiac muscle tissue development|
|actin-dependent ATPase activity|
|cardiac muscle adaptation|
|cardiac muscle hypertrophy in response to stress|
|muscle hypertrophy in response to stress|
|muscle myosin complex|
|adult heart development|
|myosin filament|
|cardiac muscle fiber development|
|microfilament motor activity|
|striated muscle adaptation|
|regulation of the force of heart contraction|
|cardiac muscle hypertrophy|
|myofibril|
|cardiac atrium morphogenesis|
|striated muscle hypertrophy|
|muscle adaptation|
|muscle hypertrophy|
|myosin complex|
|cardiac atrium development|
|actin-myosin filament sliding|
|muscle filament sliding|
|sarcomere organization|
|ventricular cardiac muscle tissue morphogenesis|
|sarcomere|
|ventricular cardiac muscle tissue development|
|muscle fiber development|
|cardiac muscle cell development|
|regulation of heart growth|
|cardiac cell development|
|myofibril assembly|
|stress fiber|
|cardiac muscle tissue morphogenesis|
|cardiac ventricle morphogenesis|
|cardiac muscle contraction|
|muscle tissue morphogenesis|
|regulation of ATPase activity|
|heart contraction|
|muscle organ morphogenesis|
|cardiac muscle cell differentiation|
|actin-mediated cell contraction|
|BMP signaling pathway|
|canonical Wnt signaling pathway|
|regulation of organ growth|
|regulation of heart rate|
|heart process|
|cellular component assembly involved in morphogenesis|
|cellular response to BMP stimulus|
|response to BMP|
|striated muscle contraction|
|actin filament-based movement|
|actomyosin structure organization|
|cardiocyte differentiation|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|Z disc|
|striated muscle cell development|
|muscle cell development|
|cardiac muscle tissue development|
|cardiac chamber development|
|regulation of blood pressure|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|striated muscle cell differentiation|
|calmodulin binding|
|actin filament binding|
|ATP metabolic process|
|protein dephosphorylation|
|ATPase activity|
|regulation of heart contraction|
|muscle cell differentiation|
|muscle contraction|
|heart morphogenesis|
|striated muscle tissue development|
|regulation of blood circulation|
|muscle organ development|
|muscle tissue development|
|muscle system process|
|dephosphorylation|
|regulation of developmental growth|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|in utero embryonic development|
|blood circulation|
|circulatory system process|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|supramolecular fiber organization|
|protein kinase binding|
|muscle structure development|
|actin cytoskeleton organization|
|cellular response to growth factor stimulus|
|heart development|
|response to growth factor|
|tissue morphogenesis|
|actin filament-based process|
|regulation of system process|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|regulation of growth|
|enzyme linked receptor protein signaling pathway|
|organelle assembly|
|cellular component morphogenesis|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|animal organ morphogenesis|
|embryo development|
|cytoskeleton organization|
|cell-cell signaling|
|cellular response to endogenous stimulus|
|regulation of hydrolase activity|
|response to endogenous stimulus|
|ATP binding|
|movement of cell or subcellular component|
|cell development|
|tissue development|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5621
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MYH6 Expression in NALM6 Cells: -4.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>