MYH7B [The Human Chemical-Genetic Interaction Map Project]

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======= MYH7B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MYH7B
  * **<color #00a2e8>Official Name</color>**: myosin heavy chain 7B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57644|57644]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/A7E2Y1|A7E2Y1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MYH7B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MYH7B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609928|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The myosin II molecule is a multi-subunit complex consisting of two heavy chains and four light chains. This gene encodes a heavy chain of myosin II, which is a member of the motor-domain superfamily. The heavy chain includes a globular motor domain, which catalyzes ATP hydrolysis and interacts with actin, and a tail domain in which heptad repeat sequences promote dimerization by interacting to form a rod-like alpha-helical coiled coil. This heavy chain subunit is a slow-twitch myosin. Alternatively spliced transcript variants have been found, but the full-length nature of these variants is not determined. [provided by RefSeq, Mar 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in muscle contraction. {ECO:0000269|PubMed:11919279}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Myosin N|
|Myosin head|
|Myosin tail 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cardiac myofibril|
|myosin filament|
|motor activity|
|actin filament binding|
|ATP binding|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|-1.73|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-1.72|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|-1.7|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|1.71|
|[[:results:exp148|SB202190 10μM R03 exp148]]|1.74|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|1.85|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|1.87|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|1.87|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|1.99|
|[[:results:exp453|B02 10μM R08 exp453]]|2.01|
|[[:results:exp131|L-74142 5μM R03 exp131]]|2.17|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:psma7|PSMA7]]|0.485|
|[[:human genes:d:ddtl|DDTL]]|0.484|
|[[:human genes:d:dhx38|DHX38]]|0.466|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.463|
|[[:human genes:p:psma6|PSMA6]]|0.462|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.458|
|[[:human genes:g:golga8o|GOLGA8O]]|0.455|
|[[:human genes:c:chd4|CHD4]]|0.451|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.449|
|[[:human genes:k:kctd17|KCTD17]]|0.445|
|[[:human genes:s:smg7|SMG7]]|0.44|
|[[:human genes:z:zfand5|ZFAND5]]|0.439|
|[[:human genes:p:psmd11|PSMD11]]|0.434|
|[[:human genes:p:psmd2|PSMD2]]|0.43|
|[[:human genes:t:twistnb|TWISTNB]]|0.428|
|[[:human genes:p:psmd14|PSMD14]]|0.427|
|[[:human genes:c:copa|COPA]]|0.426|
|[[:human genes:e:exosc9|EXOSC9]]|0.426|
|[[:human genes:c:cgb2|CGB2]]|0.426|
|[[:human genes:t:terf1|TERF1]]|0.42|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.418|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.417|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.417|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.417|
|[[:human genes:p:psmb2|PSMB2]]|0.415|
|[[:human genes:r:rps12|RPS12]]|0.414|
|[[:human genes:p:pan3|PAN3]]|0.412|
|[[:human genes:s:s1pr4|S1PR4]]|0.412|
|[[:human genes:m:mt1e|MT1E]]|0.409|
|[[:human genes:r:rnpc3|RNPC3]]|0.407|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.407|
|[[:human genes:m:mepce|MEPCE]]|0.406|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.405|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.405|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.404|
|[[:human genes:p:pole|POLE]]|0.404|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.404|
|[[:human genes:z:znf830|ZNF830]]|0.403|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.403|
|[[:human genes:p:polr2d|POLR2D]]|0.402|
|[[:human genes:p:psmb4|PSMB4]]|0.402|
|[[:human genes:s:slc6a17|SLC6A17]]|0.401|
|[[:human genes:r:rad51|RAD51]]|0.401|
|[[:human genes:c:cox7a2l|COX7A2L]]|0.401|
|[[:human genes:t:terf2|TERF2]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1946
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MYH7B Expression in NALM6 Cells: 3.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>