MYLK2 [The Human Chemical-Genetic Interaction Map Project]

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======= MYLK2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MYLK2
  * **<color #00a2e8>Official Name</color>**: myosin light chain kinase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=85366|85366]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H1R3|Q9H1R3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MYLK2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MYLK2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606566|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a myosin light chain kinase, a calcium/calmodulin dependent enzyme, that is exclusively expressed in adult skeletal muscle. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N- terminus of a myosin light chain. {ECO:0000269|PubMed:11733062}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|Pkinase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of muscle filament sliding|
|myosin light chain kinase activity|
|skeletal muscle satellite cell differentiation|
|myosin light chain binding|
|calmodulin-dependent protein kinase activity|
|neuromuscular synaptic transmission|
|regulation of actin filament-based movement|
|sarcomere|
|skeletal muscle cell differentiation|
|cardiac muscle tissue morphogenesis|
|cardiac muscle contraction|
|muscle tissue morphogenesis|
|peptidyl-threonine phosphorylation|
|heart contraction|
|muscle organ morphogenesis|
|peptidyl-threonine modification|
|heart process|
|striated muscle contraction|
|skeletal muscle tissue development|
|skeletal muscle organ development|
|regulation of muscle contraction|
|cardiac muscle tissue development|
|protein autophosphorylation|
|calmodulin binding|
|regulation of muscle system process|
|heart morphogenesis|
|muscle contraction|
|striated muscle tissue development|
|muscle organ development|
|muscle tissue development|
|muscle system process|
|regulation of intracellular transport|
|regulation of actin filament-based process|
|blood circulation|
|circulatory system process|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|trans-synaptic signaling|
|synaptic signaling|
|muscle structure development|
|heart development|
|tissue morphogenesis|
|regulation of system process|
|circulatory system development|
|peptidyl-amino acid modification|
|regulation of cellular localization|
|animal organ morphogenesis|
|protein phosphorylation|
|regulation of cellular component movement|
|cell-cell signaling|
|phosphorylation|
|ATP binding|
|tissue development|
|regulation of transport|
|system process|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.96|
|[[:results:exp392|PT-1 25μM R07 exp392]]|1.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3829
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.63 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MYLK2 Expression in NALM6 Cells: 0.63'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>