MYLK2

Entrez Summary: This gene encodes a myosin light chain kinase, a calcium/calmodulin dependent enzyme, that is exclusively expressed in adult skeletal muscle. [provided by RefSeq, Jul 2008].
UniProt Summary: Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N- terminus of a myosin light chain. {ECO:0000269|PubMed:11733062}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Thimerosal 0.85μM R08 exp529	-1.96
PT-1 25μM R07 exp392	1.87

Pkinase Tyr
Pkinase

regulation of muscle filament sliding
myosin light chain kinase activity
skeletal muscle satellite cell differentiation
myosin light chain binding
calmodulin-dependent protein kinase activity
neuromuscular synaptic transmission
regulation of actin filament-based movement
sarcomere
skeletal muscle cell differentiation
cardiac muscle tissue morphogenesis
cardiac muscle contraction
muscle tissue morphogenesis
peptidyl-threonine phosphorylation
heart contraction
muscle organ morphogenesis
peptidyl-threonine modification
heart process
striated muscle contraction
skeletal muscle tissue development
skeletal muscle organ development
regulation of muscle contraction
cardiac muscle tissue development
protein autophosphorylation
calmodulin binding
regulation of muscle system process
heart morphogenesis
muscle contraction
striated muscle tissue development
muscle organ development
muscle tissue development
muscle system process
regulation of intracellular transport
regulation of actin filament-based process
blood circulation
circulatory system process
anterograde trans-synaptic signaling
chemical synaptic transmission
trans-synaptic signaling
synaptic signaling
muscle structure development