MYO1D [The Human Chemical-Genetic Interaction Map Project]

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======= MYO1D =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MYO1D
  * **<color #00a2e8>Official Name</color>**: myosin ID
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4642|4642]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O94832|O94832]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MYO1D&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MYO1D|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606539|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Myosin TH1|
|Myosin head|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|early endosome to recycling endosome transport|
|actin-dependent ATPase activity|
|axolemma|
|apical dendrite|
|microfilament motor activity|
|vesicle-mediated transport between endosomal compartments|
|smooth endoplasmic reticulum|
|plasma membrane raft|
|myelin sheath|
|myosin complex|
|brush border|
|calcium-dependent protein binding|
|negative regulation of phosphatase activity|
|negative regulation of dephosphorylation|
|perikaryon|
|cell cortex|
|cytosolic transport|
|regulation of phosphatase activity|
|basolateral plasma membrane|
|calmodulin binding|
|actin filament binding|
|regulation of dephosphorylation|
|protein domain specific binding|
|cytoplasmic vesicle|
|early endosome|
|endosome|
|axon|
|neuron projection|
|neuronal cell body|
|forebrain development|
|negative regulation of hydrolase activity|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|brain development|
|head development|
|negative regulation of catalytic activity|
|central nervous system development|
|negative regulation of molecular function|
|regulation of hydrolase activity|
|ATP binding|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|establishment of protein localization|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|-1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.486|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16501
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MYO1D Expression in NALM6 Cells: 4.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>