MYOF [The Human Chemical-Genetic Interaction Map Project]

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======= MYOF =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MYOF
  * **<color #00a2e8>Official Name</color>**: myoferlin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26509|26509]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NZM1|Q9NZM1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MYOF&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MYOF|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604603|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|C2|
|FerA|
|FerB|
|FerI|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|T-tubule organization|
|plasma membrane repair|
|glycerol metabolic process|
|myoblast fusion|
|alditol metabolic process|
|regulation of vascular endothelial growth factor receptor signaling pathway|
|syncytium formation by plasma membrane fusion|
|cell-cell fusion|
|syncytium formation|
|myotube differentiation|
|muscle fiber development|
|cellular response to heat|
|caveola|
|plasma membrane organization|
|phospholipid binding|
|response to heat|
|polyol metabolic process|
|striated muscle cell development|
|cytoplasmic vesicle membrane|
|muscle cell development|
|cellular carbohydrate metabolic process|
|response to temperature stimulus|
|nuclear envelope|
|striated muscle cell differentiation|
|nuclear membrane|
|muscle cell differentiation|
|muscle contraction|
|cytoplasmic vesicle|
|regulation of cellular response to growth factor stimulus|
|muscle system process|
|alcohol metabolic process|
|blood circulation|
|circulatory system process|
|endomembrane system organization|
|organic hydroxy compound metabolic process|
|carbohydrate metabolic process|
|muscle structure development|
|wound healing|
|response to wounding|
|intracellular membrane-bounded organelle|
|membrane organization|
|anatomical structure formation involved in morphogenesis|
|response to abiotic stimulus|
|cell development|
|cellular response to stress|
|small molecule metabolic process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.7|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|1.76|
|[[:results:exp69|Deguelin 0.05μM R02 exp69]]|1.8|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|1.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3301
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MYOF Expression in NALM6 Cells: -1.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>