MZT1 [The Human Chemical-Genetic Interaction Map Project]

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======= MZT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MZT1
  * **<color #00a2e8>Official Name</color>**: mitotic spindle organizing protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=440145|440145]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q08AG7|Q08AG7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MZT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MZT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613448|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for gamma-tubulin complex recruitment to the centrosome. {ECO:0000269|PubMed:20360068}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MOZART1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|gamma-tubulin complex localization|
|interphase microtubule organizing center|
|microtubule nucleation by interphase microtubule organizing center|
|gamma-tubulin ring complex|
|microtubule nucleation by microtubule organizing center|
|microtubule nucleation|
|cellular protein-containing complex localization|
|microtubule polymerization|
|mitotic spindle assembly|
|microtubule polymerization or depolymerization|
|mitotic spindle organization|
|protein polymerization|
|spindle assembly|
|microtubule cytoskeleton organization involved in mitosis|
|spindle|
|mitotic nuclear division|
|spindle organization|
|protein-containing complex localization|
|nuclear division|
|organelle fission|
|supramolecular fiber organization|
|microtubule cytoskeleton organization|
|centrosome|
|mitotic cell cycle process|
|microtubule-based process|
|mitotic cell cycle|
|organelle assembly|
|cellular protein-containing complex assembly|
|cell cycle process|
|cytoskeleton organization|
|cell cycle|
|protein-containing complex assembly|
|cellular protein localization|
|cellular macromolecule localization|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp318|ABT-702 5μM R07 exp318]]|-1.76|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-1.7|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|1.71|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.45|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 50/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|4/28|
|blood|0/28|
|bone|3/26|
|breast|6/33|
|central nervous system|4/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|1/20|
|lung|5/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|3/24|
|peripheral nervous system|1/16|
|plasma cell|3/15|
|prostate|1/1|
|skin|2/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|3/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3622
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MZT1 Expression in NALM6 Cells: 5.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>